Let  me start this editorial with an unusual feature. The first paper, among the 5 selected for this issue, is in fact the text of a conversation of the Journal of Clinical investigation (JCI) editors  with Professor  Peter Agre, awarded a few years ago the Chemistry Nobel  Prize for his seminal work on aquaporins, the ubiquitous water channels. The content of this interview may be of interest to young nephrologists, especially when Professor Agre describes how  his research interests developed over the years.

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