| Title
of the article |
Hemodialysis reduces plasma apolipoprotein C-I concentration making VLDL a better substrate for lipoprotein lipase. |
| Authors |
Dautin G, Soltani Z, Ducloux D, Gautier T, Pais de Barros JP, Gambert P, Lagrost L, Masson D. |
| Journal
|
Kidney Int. 2007 Oct;72(7):871-8. Epub 2007 Aug 1. |
| Subject
Consultant |
C. Basile |
| Score
(1 to 3 stars) |
** |
| Comments |
Apolipoprotein Cs (apoC-1, apoC-II, and apoC-III) are lipoprotein components that have regulatory effects on enzymes involved in lipoprotein metabolism. Owing to their low molecular weights, apoCs can adsorb onto and/or pass through dialysis membranes. This study shows that apoC-I losses during HD might be beneficial by improving the ability of VLDL to be a substrate for LPL thus improving plasma triglyceride metabolism. |
