| Title
of the article |
A diffusion-adjusted regional blood flow model to predict solute kinetics during haemodialysis.
|
| Authors |
Schneditz D, Platzer D, Daugirdas JT. |
| Journal
|
Nephrol Dial Transplant. 2009 Jul;24(7):2218-24. Epub 2009 Feb 11. |
| Subject
Consultant |
C. Basile |
| Score
(1 to 3 stars) |
** |
| Comments |
Sequestration of creatinine, in both erythrocytes and other cells, has complicated the widespread application of creatinine kinetics in haemodialysis. The goal of this study was to determine whether creatinine kinetics could be described using a regional blood flow (RBF) model that also incorporated diffusion between intra- and extracellular fluids. This study suggests that a diffusion-adjusted regional blood flow (DA-RBF) model can be used to explain compartmentalization of creatinine or urea throughout the body during haemodialysis, although possible additional compartmentalization of urea in erythrocytes, and perhaps in the tissues, still needs to be accounted for. |
