SUBJECT CONSULTANT REVIEW

Title of the article
Effect of treatment spacing and frequency on three measures of equivalent clearance, including standard Kt/V.
Authors

Daugirdas JT, Tattersall J.

Journal

Nephrol Dial Transplant. 2010 Feb;25(2):558-61. Epub 2009 Sep 10.

Subject Consultant
C. Basile
Score (1 to 3 stars)
**
Comments
The authors examined the sensitivity of three different equivalent clearances to the spacing of haemodialysis treatments as well as to frequency. All three equivalent clearances increased on moving from three to six sessions per week, with standard Kt/V having the greatest increase. Standard Kt/V is not at all sensitive to spacing. Alternative clearances based on the TAC or peak concentration have the advantage of taking both spacing and frequency into account.