A patient on peritoneal dialysis with weight gain and edema

by Dr. E. Fleischmann
Department of Clinical Medicine IV, Division of Nephrology and Hypertensiology,
Friedrich-Alexander University Erlangen-Nuremberg
Erlangen, Germany

 

A 57 year old woman treated with CAPD for ESRD due to FSGS presented with complaints of weight gain, edema, reduced physical well-being and loss of appetite. She started CAPD 42 months ago. Concomitant diseases were arterial hypertension, goiter and hysterectomy due to myoma.
On examination her blood pressure was 142/87 mm HG, heart rate 73 bpm, bodyweight 81,5 kg, normal SI and SII, without murmur, respiration was unremarkable, she had + peripheral edema. At present she was using as PD prescription a fill volume of 2000 ml with glucose concentration of 1x 2,27 %, 2 x 3,86% and 1 x icodextrin revealing an ultrafiltration of 1350 mls per day with residual urine volume of 200 ml.

Laboratory: Hemoglobin 10,3 g/L, Erythrocytes 3,25 mio/µl, wbc 8,62 x 10 3/µl, thrombocytes 398 8,62 x 10 3/µl, creatinine 9,48 mg/dl, urea 56 mg/dl, albumin 3,13 g/dl, sodium 139 mmol/l, potassium 3,92 mmol/l, calcium 2,51 mmol/l, phosphate 4,49 mmol/l , CaxPo4 45,1, iPTH 239 pg/ml, CRP 0,90 mg/dl

Question 1) - What information is needed for further work up of the patient?

a) Ultrafiltration rate
b) Residual renal function
c) History of fluid and salt intake
d) clearance of urea and creatinine
e) peritoneal equilibrium test
f) all of the above