The elderly patient with acute mental confusion and arrhythmia

wagenlehner

by Florian M.E. Wagenlehner, Kurt G. Naber
Urology Clinic, St. Elisabeth Hospital, Straubing, Germany

 


The case

A 71-year-old woman was referred to the Internal Medicine emergency room on April 14th . The accompanying husband explained that she suddenly became confused during the night and later turned somnolent.
Her recent clinical history was uneventful, except for an episode of lower abdominal pain 4 days previously, which improved after scopolamine butylbromide. She had experienced similar symptoms 3 months earlier and was fully asymptomatic in between.
The physical examination showed a confused patient, with a heart rate of 128/min (atrial fibrillation at ECG), low-grade fever (37.8°C), normal auscultation of the lung and abdominal findings, no costovertebral tenderness, no skin abnormalities, no meningism or focal neurological signs.
The patient was admitted to the Intensive Therapy Unit with the tentative diagnosis of apoplexy, atrial fibrillation and fever of unknown origin. Blood and imaging tests, including cerebral CT scan, are reported in table I.
Three days later, while afebrile, she developed an episode of acute psychosis in the absence of meningism or focal neurological signs; she was then transferred to an external psychiatric clinic. However, the following day she developed high fever, up to 41°C, with chills; cerebral CT scan was repeated and was again normal. She was transferred to the Neurological Clinic with the tentative diagnosis of meningo-encephalitis: meningism was present, focal neurological signs were absent.
Further blood tests are reported in table I.


Blood and imaging tests


Microscopy of the liquor showed 420/3 cells (normal up to 5/3) and multiple Gram-negative rods. Liquor glucose was 65 mg/dl, total protein 61 mg/dl (normal 15-45) and lactate was 4.3 mmol/l (normal 1.2-2.1). Empirical antibiotic therapy was started with ceftriaxone, gentamicin and ampicillin; in the following days, in the absence of a clinical response, fosfomycin and metronidazole were added to cover Gram-positive and anaerobic bacteria.

Question 1) - What important test to discover the cause of sepsis is missing?
(Only ONE answer is correct)

a) Abdominal ultrasounds
b) TC scan
c) PET scan
d) Granulocyte Scinitgraphy