CASE STUDIES

wcn2003

PAEDIATRIC CLINICAL NEPHROLOGY CONFERENCE

Glomerulonephritis

Chair: R. Coppo, Turin, Italy

J.C. Davin, Amsterdam, The Netherlands

Case of a boy presenting with microscopic hematuria


By R. Coppo and S. Emancipator

Prof R. Coppo
Prof S. Emancipator
Prof R. Coppo
Director of the Nephrology, Dialysis and Transplantation Department
Regina Margherita Hospital
Turin, Italy
Prof S. Emancipator
Professor at Institute of Pathology
Case Western Reserve University
Cleveland, OH, USA

 

 

Comment

Hence, a renal biopsy was performed. A fragment of renal cortex containing 21 glomeruli was available for light microscopic examination. The light microscopic changes detected by Steven Emancipator are depicted.

Figure 1
Figure 2
Figure 1: Focal and segmental increases in mesangial matrix and mesangial cellularity were present in 17 of the 21 glomeruli in the biopsy; one glomerulus (not depicted) showed total global glomerulosclerosis.
Figure 2: A small non-circumferential florid crescent occupied part of the urinary space in 1 of 21 glomeruli.
Figure 3
Figure 4
Figure 3: Small segments of sclero-hyalinosis with flocculent capsular adhesion were present in 2 of 21 glomeruli.
Figure 4: By immunofluorescence, intense (+++) IgA was deposited in mesangial areas with some extension to subendothelial areas; although not shown, there was associated C3(+++) and IgG(+) as well.

 

Question 2