| Title
of the article |
Cardiovascular outcomes and all-cause mortality: exploring the interaction between CKD and cardiovascular disease |
| Authors |
Weiner DE, Tabatabai S, Tighiouart H, Elsayed E, Bansal N, Griffith J, Salem DN, Levey AS, Sarnak MJ |
| Journal
|
Am J Kidney Dis 2006;48(3):392-401. |
| Subject
Consultant |
F. Garcia Lopez |
| Score
(1 to 3 stars) |
*** |
| Comments |
Another report of a pooled subject-level data from 4 cardiovascular cohort studies that focuses on the interrelationship between CKD (defined as an estimated GFR ≥ 15 ml/min/1.73 m2 and < 60 ml/min/1.73 m2) and cardiovascular disease (CVD) with regard to the risk for adverse cardiac events and mortality in the US community. Unexpectedly, no effect modification of CKD on CVD was found, that is, CKD did not confer a greater magnitude of risk for cardiovascular events and all-cause mortality in individuals with CVD in addition to the sum of the risks inherent to CKD and CVD. Despite some limitations, this large study virtually rules out a significant clinical interaction between CKD and CVD on cardiovascular mortality. |
