April 25th, 2008

The Leeuwenhorst Conference Center

Noordwijkerhout, The Netherlands

Registration deadline:

15 March 2008

ERA-EDTA CME Activities

Chair-person: R. Coppo (Italy)

Secretary: A.L.M. De Francisco (Spain)

Members: J. Floege (Germany)

R. Vanholder (Belgium)

A. Wiecek (Poland)

C. Zoccali (Italy)

J. Cannata-Andia, ERA-EDTA President (Spain)

CME Courses Coordinators:

Basic Science and Clinical Nephrology: R. Coppo (Italy) and P. Ronco (France).

Chronic Renal Failure, Hypertension and Clinical Epidemiology: C. Zoccali (Italy) and G. London (France).

Dialysis: R. Vanholder (Belgium), S. Davies (UK) and C. Wanner (Germany).

Transplantation: C. Ponticelli (Italy) and J. Grinyo (Spain).

Collaboration with ISN for courses in Eastern Europe: N. Lameire (Belgium), A. Covic (Romania).

Course organizers:	Prof.dr. M.R. Daha
	Prof.dr. J.W. de Fijter
	Dr. S.P. Berger
	Dr. Cees van Kooten
Assistance:	Ms. Eva van der Kwast
	Email: evdkwast@lumc.nl

Aim of the course:

The complement system is a major player of our innate immune defense and is directly involved in many beneficial and less beneficial effects, such as microbial defense or host tissue injury.

The aim of this one full day advanced course is to provide clinicians and basic scientists a full overview of the role of complement in renal disease and transplantation. The course will cover basic mechanisms of complement activation, the involvement of complement in age-related macular degeneration, hemolytic uremic syndrome, membranoproliferative glomerulonephritis, experimental forms of renal disease and clinical transplantation including kidney/pancreas transplantation.

The faculty consists of experts in the field of basic complement research and well known clinicians which offers us the possibility of in depth discussions on the role of complement in clinical medicine.

Number of participants:	max. 100
Registration deadline:	15 March 2008
Registration and lunch/dinner:	€75,-
Hotel:	€120,- p.p. p.n./ €75,- p.p.p.n. for a shared room
Course Scientific Committee:	M.R. Daha, S.P. Berger, Cees van Kooten,
	J.W. de Fijter
Administrative contact:	Eva van der Kwast (evdkwast@lumc.nl)
Social activities:	Saturday 26 April 2008, see additional information

REGISTRATION FORM

SCIENTIFIC PROGRAMME

Prof.dr. Mohamed R. Daha
Complement, introduction and overview

Prof.dr. B. Paul Morgan
Fluid phase and membrane regulators of complement

Prof. Tim Goodship
Genomic mutations affecting complement genes in renal disease

Prof. Marina Norris
Kidney transplantation in hemolytic uremic syndrome

Dr. Veronique Fremeaux-Bachhi
Genetic mutations resulting in gain of function of complement in hemolytic uremic syndrome (HUS)

Dr. Matthew Pickering
The molecular pathogenesis of membranoproliferative glomerulonephritis (MPGN2) and hemolytic uremic syndrome (aHUS)

Prof. Steven Sacks
New boundaries for complement in renal disease

Dr. Stefan Berger
Complement polymorphisms and allograft outcome

Prof. Edward Medof
Underlying mechanisms of age-related macular degeneration (AMD) and hemolytic uremic syndrome (HUS)

Dr. Cees van Kooten
The immune regulatory role of complement in the clearance of apoptotic cells

Dr. Anja Roos
Diagnostics of complement in clinical medicine

Additional information

The advanced ERA-EDTA CME Course “Complement in renal disease and transplantation” will be held on 25 April 2008 in the Leeuwenhorst Conference Center, close to Leiden. The center can be reached easily by air (Amsterdam, Schiphol Airport) or by public transportation.

The schedule will be as follows:
Arrivals are planned for Thursday 24 April, 2008 in the afternoon or early evening. Registration will be between 4-8PM on Thursday, dinner starts at 7.30PM.

The scientific programme will start at 8.30AM on Friday 25 April, 2008 and will end at 5PM.

At this point all participants have the following options:

You can leave.
You can stay overnight at the hotel and leave the next day.
Participate in the social programme. For those who would like to stay another day, we plan to organize a visit to the Keukenhof flower gardens followed by the yearly flower parade which happens to be exactly on Saturday 26 April. During this day we will take a bus drive to different locations, including a lunch break. At the end of the day we will drop you off around 5PM at Schiphol airport or at the Leiden Central train station. The costs for this social event, including dinner on Friday evening, lunch, entrance to the flower garden, will be €100,- per person. This price does not include hotel costs on Friday evening. Visiting the bulb fields around this time of the year is really a great opportunity.

How the register:

Forms to register for the different activities will be available soon. Deadline for registration is 15 March 2008 and will be on a first come first serve basis.