SUBJECT CONSULTANT REVIEW

Title of the article
Comparison of 10-mg and 5-mg Warfarin Initiation Nomograms Together with Low-Molecular-Weight Heparin for Outpatient Treatment of Acute Venous Thromboembolism. A Randomized, Double-Blind, Controlled Trial.
Authors
Kovacs MJ, Rodger M, Anderson DR, Morrow B, Kells G, Kovacs J, Boyle E, Wells PS.
Journal
Ann Intern Med. 2003 May 6;138(9):714-9.
Subject Consultant
F. Mallamaci
Score (1 to 3 stars)
**
Cross referencing
 
Comments
201 of 210 consecutive patients with objectively confirmed diagnoses of acute venous thromboembolism randomly received a 10-mg or 5-mg dose of warfarin. The 10-mg warfarin initiation nomogram was proven to be superior to the 5-mg nomogram because it allows more rapid achievement of a therapeutic INR.