| Title
of the article |
Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells. |
| Authors |
Barua RS, Ambrose JA, Srivastava S, DeVoe MC, Eales-Reynolds LJ. |
| Journal
|
Circulation. 2003 May 13;107(18):2342-7. |
| Subject
Consultant |
F. Mallamaci |
| Score
(1 to 3 stars) |
** |
| Cross
referencing |
Basic Science |
| Comments |
In vitro, human coronary artery endothelial cells (HCAECs) show decreased nitric oxide (NO) production and endothelial nitric oxide synthase (eNOS) activity in the presence of increased eNOS ,when exposed to smokers' serum and also confirms that oxidative stress plays a central role in smoking-mediated dysfunction of NO biosynthesis in endothelial cells. |
