SUBJECT CONSULTANT REVIEW

Title of the article
Telmisartan, ramipril, or both in patients at high risk for vascular events
Authors
ONTARGET Investigators, Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P, Anderson C.
Journal
N Engl J Med. 2008 Apr 10;358(15):1547-59
Subject Consultant
F. Mallamaci
Score (1 to 3 stars)
***
Comments
Telmisartan was equivalent to ramipril in patients with vascular disease or high-risk diabetes and was associated with less angioedema. The combination of the two drugs was associated with more adverse events without an increase in benefit.