SUBJECT CONSULTANT REVIEW

Title of the article
Acute Renal Allograft Rejection: Diagnostic Significance of Focal Peritubular Capillary C4d.
Authors

Kayler LK, Kiss L, Sharma V, Mohanka R, Zeevi A, Girnita A, Shapiro R, Randhawa PS.

Journal
Transplantation. 2008 Mar 27;85(6):813-820
Subject Consultant
V. Nickeleit
Score (1 to 3 stars)
*
Comments
The study indicates that focal C4d staining (based on the analysis of paraffin embedded tissue sections only) carries diagnostic significance. Data on corresponding circulating donor specific antibodies are somwhat scant, but should not distract too much from the overall take home message.