| Title
of the article |
Donor and recipient contribution to transplant vasculopathy in chronic renal transplant dysfunction. |
| Authors |
Boersema M, Rienstra H, van den Heuvel M, van Goor H, van Luyn MJ, Navis GJ, Popa ER, Hillebrands JL. |
| Journal
|
Transplantation. 2009 Dec 27;88(12):1386-9 |
| Subject
Consultant |
V. Nickeleit |
| Score
(1 to 3 stars) |
** |
| Comments |
According to the presented data approximately 3% - 11% of neointimal smooth muscle cells in the setting of sclerosing transplant vasculopathy (=so-called chronic vascular rejection) are recipient derived. These data indicate that the vast majority of de-novo myofibroblasts populating neo-intimal arterial zones in chronic rejection are donor derived and presumably of donor vascular medial layer origin. While recipient derived cell elements (including myofibroblast precursors) infiltrating transplant vessels may potentially be accessible to therapy, no compelling treatment options are available to stop donor derived myofibroblast proliferation and the progression of chronic vascular rejection. |
