NDT-EDUCATIONAL

Editorial issue 333

The first 3 papers of this 333rd issue of NDT-E were very recently published in the JCI. The first 2 ones originate from the German group of Jens Titze. In a series of elegant experiments, this group extends seminal observations initially made in space travellers on the existence of salt storage in skin in an osmotically inactive form. These observations have now triggered, as is always the case with top science, additional questions that are now progressively addressed. The first one by N Rakova et al has the title "Increased salt consumption induces body water conservation and decreases fluid intake". The second one by K Kitada is "High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation".
In the third one, ML Zeidel discusses the new studies under the title "Salt and water : not so simple". Indeed, science usually progresses with the recognition of complexity.

The last 2 papers, clinical ones, are recent CKJ ones. C Thongprayoon report on "Acute kidney injury in octogenarians after heart valve replacement surgery: a study of two periods over the last decade". Lastly, S Shah et al report on "Immunoglobulin levels and infection risk with rituximab induction for anti-neutrophil cytoplasmic antibody–associated vasculitis".

CME lectures   
The 2 CME Lectures of this issue are from top experts in the glomerular field. Pr Manuel Praga (Madrid, Spain) discusses "Calcineurin inhibitors in membranous nephropathy".
And Pr Pierre Ronco (Paris, France). "The PLA2R autoantigen: from pathophysiology to patients' care".

Enjoy NDT-Educational!

Prof. Michel Jadoul
Editor-in-Chief NDT-Educational