Editorial Issue 221



New data show that obesity is associated with hypothalamic injury in both rodents and humans


In the 221th issue of NDT-E you will find three CME lectures presented at the ERA-EDTA meeting in Prague June 2011. In the first lecture Peter Barany, Stockholm, Sweden will present an update on “ADIPOKINE SIGNALING AND THE KIDNEY”. The second talk is entitled ”METABOLIC ROLE OF NATRIURETIC PEPTIDE – IS IT IMPORTANT FOR RENAL FAILURE?” and is presented by Max Lafontan, Toulouse, France. The last talk will discuss ”VASOPRESSIN AS A RISK FACTOR FOR CKD” and is presented by Ron T. Gansevoort, Groningen, Netherlands. In his talk Dr Gansevoortconcludes that both observational and interventional data support a role for vasopressin as a risk factor for progressive CKD. Moreover, future studies will need to test various interventions to block vasopressin activity. In the field of adult polycystic kidney disease there are two randomised controlled trials underway.


In this issue of NDT-E you will also find links to a number of novel and interesting full papers recently published in J Clin Invest, Kidney International, and Nephrology Dialysis Transplantation. In the first full paper, which was recently published in J Clin Invest, Joshua P. Thaler et al. report that hypothalamic inflammatory signaling was evident in both rats and mice within 1 to 3 days of consumption of a high-fat diet. Moreover, the authors found evidence of increased gliosis in the mediobasal hypothalamus of obese humans, as assessed by MRI. These intriguing data suggest that, in both humans and rodent models, obesity is associated with neuronal injury in a brain area crucial for body weight control. In this issue of NDT-E you will also find a valuable systematic review published in Kidney International by Jeff Coombes and Robert Fassett on antioxidant therapy in HD-patients. Another full paper taken from the most recent issue of Kidney International is written by Vidya Krishnamurthy et al. and shows that high dietary total fiber intake is associated with lower risk of inflammation and mortality in kidney disease. Moreover, the observed associations were stronger in magnitude in the CKD population. In the 3rd full KI paper in this issue of NDT-ECarsten Hafer et al. demonstrate that high-dose rHuEPO after kidney transplantation, had no effect on long-term graft function or histology. Finally, you will also find an original investigation published in Nephrol Dial Transpl by Li-Ping Chen et al. that, based on a cohort of 253 Taiwanese HD-patients, show that moderate to severe periodontitis is associated with metabolic syndrome. Thus, whether or not improved oral health reduces the risk of metabolic syndrome is something that needs to be addressed in further studies.


Please also take some time to answer the survey on calcific uremic arteriolopathy (calciphylaxis) in this issue of NDT-E.


Enjoy your NDT-E!


Peter Stenvinkel, Editor-in-chief