Editorial Issue 222


Learn more about iga nephropathy in this issue of NDT-Educational



In the 222nd issue of NDT-E you will find four interesting CME lectures presented at the ERA-EDTA meeting in Prague June 2011. In the first lecture Dr Rosanna Coppo, Turin, Italy presents an update on “IS A LEGACY EFFECT POSSIBLE FOR IGA NEPHROPATHY?” She concludes her talk by stating that we should consider early treatment before a no-return phase of the immune committment. Moreover, the renal community should search for new drugs targeting the mucosal immunity with little systemic effect in IGAN.Finally, we should focus future reserach on potentiating the recovery capacity and investigate the possibility of increasing T reg cell activity. The second talk is entitled ” GENOMICS IN IGA NEPHROPATHY” and is presented by Dr Francesco Paolo Schena, Bari, Italy. The 3rd talk discusses ”RECURRENCE OF IGA NEPHROPATHY AFTER KIDNEY TRANSPLANTATION” and is presented by Dr Jürgen Floege, Aachen, Germany. In this talk Dr Floege tells us that recurrent IgAN results in graft failure in 8-23% and graft loss in about 1-16% of the patients at 5-6 years. In the final talk Dr Ian Roberts, Oxford, UK will discuss ”HISTOLOGIC MARKERS INDICATING THE NEED FOR THERAPEUTIC INTERVENTION IN IGA NEPHROPATHY”.


You will also find links to a number of novel and useful full papers recently published in Kidney International, Nephrology Dialysis Transplantation (NDT) and J Nephrology. The first full paper, by Julia Hofstra and Jack Wetzels was published in the January issue of NDT and will teach you more about the management of membranous nephopathy. In another full paper published in NDT, Paola Ciceri et al. present in vitro preliminary data that suggest a potential role for ascorbic acid combined with inorganic phosphate in worsening vascular calcification. In another interesting paper Geir Mjøen et al. studied all live kidney donors in Norway during the period 1963–2007 and found that overall and cardiovascular mortality were lower for previous kidney donors than for matched controls. However, as age-stratified death rates were elevated for the oldest group of donors this requires further studies. In a full paper from Kidney Int Xiaolan Zhang et al. conclude that specific renal pathologic lesions can be modeled by composite biomarkers to noninvasively follow and adjust the treatment of lupus nephritis reflecting renal injury. Finally, you will also find an original investigation based on a cohort of 80 Turkish nondiabetic PD patients followed for 5 years published in J Nephrology by Hamad Dheir et al. that shows that HbA1c levels predict fatal and nonfatal cardiovascular events.


Please also take some of your time to answer the survey on calcific uremic arteriolopathy (calciphylaxis) in this issue of NDT-E.


Enjoy your NDT-E!


Peter Stenvinkel, Editor-in-chief