Editorial issue 231

The EVOLVE trial of cinacalcet in patients with end-stage renal disease is negative


The first week of June another negative randomized controlled trial in ESRD was reported. The goal of the EVOLVE study using cinacalcet was to show a reduction in the risk of death, heart attack, unstable angina or heart failure in patients with chronic kidney disease who were receiving dialysis. Amgen reported that the results were not statistically significant and the trial did not meet its goal 


In the 231st issue of NDT-E you will find some interesting full papers to read. Kai Soo Tan establishes in a paper published in the June issue of J Clin Invest a link between glutathione deficiency in diabetes and increased susceptibility to melioidosis. Their finding may open up new therapeutic avenues to protect diabetic patients against some intracellular bacterial pathogens. In this issue of NDT-e you will also find two interesting full papers published in Nephrol Dial Transpl. In a review paper Uwe Hemman and Lutz Renders discuss the state of of living kidney donation in Europe. In the 2nd NDT paper Ditte Hansen et al. report that alfacalcidol and paricalcitol increase the plasma levels of FGF23 equally and substantially in haemodialysis patients. In a J Nephrology paper Twyla A. Moffit et al. show data consistent with a beneficial effect of micronutrient supplementation on antioxidant enzyme activity. Finally, by reading the original paper by Wei Wang et al. published in Kidney Int you will learn that the lack of corin (a protease that activates atrial natriuretic peptide) in mice impairs the adaptive renal response to high dietary salt.


In this issue of NDT-E you will also find three interesting CME lectures presented at the ERA-EDTA meeting in Prague June 2011. In the first lecture Dr Philippe Brunet, Marseille, France presents an update entitled “DOES URAEMIA CAUSE VASCULAR DYSFUNCTION?”.  He concludes that many uremic toxins are involved in endothelial and vascular toxicity. The second talk is entitled ”ARTERIAL STIFFNESS IN ADULT PATIENTS WITH CHRONIC KIDNEY DISEASES” and is presented by Dr Pierre Boutouyrie, Paris, France. The final talk is entitled ”HEART INVOLVEMENT IN CKD: FROM LARGE ARTERIES STIFFNESS TO MICROVASCULAR DISEASE?” and is presented by Dr Adrian Covic, Iasi, Romania.


Please also take some of your time to answerthe new nutritional survey.


Enjoy your NDT-E and your summer vacation!


Peter Stenvinkel, Editor-in-chief