Editorial issue 232

News on pathogenicity of lupus autoantibodies

In the 232nd issue of NDT-E, you will find five novel papers to read. Meera Krishna et al show, in a paper published in Kidney Int, that direct binding of anti-DNA antibody to antigens in the glomerular basement membrane or mesangial matrix may be critical to initiate glomerular inflammation. The authors conclude that this may accelerate and exacerbate glomerular immune complex formation in human and murine lupus nephritis. This interesting paper is commented upon by Michael Madaio who concludes that these findings provide insights into the variable disease patterns in lupus nephritis. In a review published in Kidney Int, John Daugirdas and Angelito Bernardo discuss the effects of hemodialysis on platelet count and function. In this issue of NDT-e you will also find two full papers published in Nephrol Dial Transpl. In the first paper, Fatima Guerrero et al treated rat aortic rings and human vascular smooth muscle cells in vitro with phosphate, TNF, calcitriol and paricalcitol and showed that treatment with paricalcitol resulted in a more marked anti-inflammatory effect than treatment with calcitriol. Moreover, paricalcitol prevented vascular calcification. In the other NDT paper, Jean-Sebastien Rachoin et al conducted a retrospective observational study of two cohorts of critically ill patients and showed that clinicians should not use a urea nitrogen to serum creatinine ratio to classify acute kidney injury in critically ill patients.


In this issue of NDT-E you will also find two CME lectures presented at the ERA-EDTA meeting in Prague June 2011. In the first lecture Dr Maïté Daroux, Boulogne-sur-Mer, France presented a paper entitled “AGEs, RAGE AND DIABETIC NEPHROPATHY. She concluded that not only uremia and diabetes promote AGE formation but also diet. The second talk was entitled ”HOW TO SLOW DOWN THE PROGRESSION OF DIABETIC NEPHROPATHY” and was presented by Dr Frederik Persson, Gentofte, Denmark. In his talk, some novel strategies for increasing Ras blockade, such as endothelin antagonists, vasopeptidase inhibitors and aldosterone synthase inhibitors, were presented.


Please also answer the new nutritional survey. The correct answers to these difficult questions with comments from the authors will be posted on NDT-E when the survey is closed.


Enjoy NDT-E and your summer vacation!


Peter Stenvinkel, Editor-in-chief