Editorial issue 235

Adipose tissue–derived mesenchymal stem cells: can they cure kidney disease? 

In this issue of NDT-E you will find three CME lectures presented at the ERA-EDTA meeting in Prague June 2011. In the first lecture Dr. Francesca Mallamaci, Reggio Calabria, Italy presents a lecture entitled “MEDICAL ASPECTS OF DEPRESSION IN DIALYSIS”. In the first slide Dr. Mallamaci shows that in the global burden of disease study major depression ranked as number two. She concludes her talk by stating that depressed CKD and dialysis patients have worse outcomes in comparison to non-depressed ones. The second talk is entitled ”MULTIDISCIPLINARY CARE MODELS” and is presented by Dr. Adeera Levin, Vancouver, Canada. The third talk is entitled ”EXERCISE REHABILITATION OUTCOMES IN CKD PATIENTS” and is presented by Dr. Evangelia Kouidi, Thessaloniki, Greece. She concludes that exercise training programs should be considered as intergral to the comprehensive care of CKD patients.


In the 235th issue of NDT-E you will also find several novel interesting papers to read. Mesenchymal stem cells are a potential therapeutic agent in renal disease and kidney transplantation. This is the topic of the first paper published in Kidney Int by Marieke Roemeling-van Rhijn et al. who show that mesenchymal stem cells of patients with renal disease have similar characteristics and functionality as those from healthy controls. Thus, as these cells were not affected by uremic serum the results of this study indicate the feasibility of autologous cell therapy in patients with renal disease. In the 2nd Kidney Int paper Nicholas Webb et al. demonstrate that in children with proteinuria, losartan and enalapril significantly reduced proteinuria without any appreciable changes in eGFR. Importantly, these effects were maintained throughout the study. In the 3rd Kidney Int paper Ziyad Al-Aly et al demonstrate in a cohort of 51,304 US veterans with an eGFR <60ml/min that greater variability in kidney function is independently associated with increased risk of death. In this issue you will also find two novel interesting papers published in the Sept issue of NDT. In the first paper Giovanni Stallone et al. report from a prospective, open-label, randomized clinical trial that rapamycin does not influence the progression of type I autosomal dominant polycystic kidney disease. In the other NDT paper Celine Foote et al. report that the survival of elderly dialysis patients is predicted by both patient and practice characteristics.Finally, this issue of NDT-E also features a Ms published in J Nephrol by Carlo Basile et al who showed that hemodynamic stability does not appear to be significantly influenced by any specific dialysate total calcium concentration.


The nutritional survey will now be closed. More than 1100 answers have been received. In the next issue of NDT-E the answers of this rather difficult survey will be discussed and there will be an opportunity for you to comment and respond on both the survey and on the nutritional aspects of kidney disease in general on the new nutritional blog moderated by Juan Jesus Carrero.  


Enjoy your NDT-E!


Peter Stenvinkel, Editor-in-chief