Editorial issue 244

Rituximab is an efficient and safe treatment in adults with steroid-dependent minimal change disease


In the 244th issue of NDT-E you will find four CME lectures presented at the ERA-EDTA meeting in Paris May 2012. Dr. Terry Cook, London, UK will present a lecture entitled “GENETIC LOCI MODULATE MACROPHAGE ACTIVITY IN GLOMERULONEPHRITIS”. The 2nd lecture is entitled ”NFΚB IN RENAL INFLAMMATION” and is presented by Dr. Alberto Ortiz, Madrid, Spain. The third lecture is presented by Dr. Charles Pusey, London, UK and is entitled “KINASE INHIBITORS IN EXPERIMENTAL GLOMERULONEPHRITIS”. The final CME lecture is presented by Dr. Christian Kurts, Bonn, Germany and is entitled ”KIDNEY DENDRITIC CELLS IN ACUTE AND CHRONIC RENAL DISEASE”.


In the 244th issue of NDT-E you will also find several novel interesting papers to read. In a paper recently published in Kidney International, Dr Helene Munyentwali et al. showed that rituximab is efficient and safe in adult patients suffering from severe steroid-dependent minimal change disease. Seventeen patients with steroid-dependent or frequently relapsing minimal change nephrotic syndrome, unresponsive to several immunosuppressive medications, were treated with rituximab and no adverse events were recorded. In another paper published in Kidney International Mariam P. Alexander et al. showed that membranous glomerulonephritis should be included in the spectrum of IgG4-R related disease and should be suspected in proteinuric IgG4-related disease patients. Nishank and Elsayed have published an interesting review in the Journal of Nephrology entitled ”Dietary phosphate: what do we know about its toxicity?”. In this issue of NDT-E you will also be able to read an Ms by Valdivielso et al. showing that soluble TWEAK is associated with atherosclerotic burden in CKD patients. This will shed some light on mechanisms of hyperphosphatemic vascular dysfunction. You will also find a a review by William H. Fissell et al. on wearable dialysis and implantable artificial kidney devices. In the 3rd and very interesting original investigation Allon N Friedman et al. show that long-chain n-3 fatty acids are strongly and independently associated with a lower risk of sudden cardiac death in hemodialysis patients. In a full review published in Nephrol Dial Transpl John J. Keaney will discuss how much contrast is safe to avoid acute kidney injury. In another NDT paper Karminder S. Gill et al. have studied red blood cell transfusion use in patients with chronic kidney disease. They have found that red blood cell transfusions are relatively common and on the rise among younger CKD patients who are anemic and progress to ESRD. Finally, Dr. Alissa Lloyd et al. have in a time-matched, case–control study studied the risk of peritonitis after an exit site infection.


In this issue of NDT-E you can do the novel bone survey in two parts; one testing your knowledge about this adynamic bone disease and one practice pattern part.


If you have any questions or comments regarding nutrition in your renal patients, do not hesitate to post them on the nutritional blog. Several interesting comments have already been posted and could be discussed. A new post by Dr. Carla Avesani has been published titled ” Are we forgetting the importance of a healthy diet?”.


Enjoy your NDT-E


Peter Stenvinkel, Editor-in-chief