Editorial issue 245

Depression affects approximately one-quarter of adults with CKD

In the 245th issue of NDT-E you will find several novel interesting papers to read. In a paper recently published in Kidney International, Dr. Tineke M De Schutter et al. showed that treatment with both magnesium carbonate and sevelamer effectively controlled serum phosphate levels in rats with CKD and reduced aortic calcification. In another interesting paper published in Kidney International Dr. Ou et al. showed that nonsteroidal anti-inflammatory drug use is associated with a cancer risk reduction in chronic dialysis patients. However, the authors also state that NSAIDS should still be used with caution in this patient group due to the side effects of gastrointestinal bleeding. Suetonia Palmer et al. have published an interesting meta-analysis in Kidney Int based on 249 populations (55,982 participants), which show that interview-defined depression affects approximately one-quarter of adults with CKD. You will also find an interesting review by Toshio Miyata et al. entitled “Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?” A paper in NDT by Biagio DiIorio shows that phosphate attenuates the anti-proteinuric effect of a very low-protein diet in CKD patients. Finally, you will find an interesting manuscript based on a RCT by Moosa Salehi et al., which shows that selenium supplementation improves the nutritional status of hemodialysis patients.

In this issue of NDT-E you will also find four CME lectures presented at the ERA-EDTA meeting in Paris May 2012. Dr. Vicente Torres, Rochester, USA presents an interesting lecture entitled “VAPTANS IN ADPKD”. The 2nd lecture is entitled ”THE MANY MASKS OF HNF1BETA-RELATED (KIDNEY) DISEASES” and is presented by Dr. Dominique Chauveau, Toulouse, France. The third lecture is presented by Dr. Giuseppe Remuzzi, Bergamo, Italy and is entitled “WHAT IS A REASONABLE ENDPOINT IN CLINICAL PKD STUDIES?”. The final CME lecture is presented by Dr. Joost P.H. Drenth, Nijmegen, Netherlands and is entitled ”SOMATOSTATIN ANALOGUES IN POLYCYSTIC LIVER DISEASE”.

In this issue of NDT-E you can do the novel bone survey in two parts; one testing your knowledge about this adynamic bone disease and one practice pattern part. You can also read an interesting new comment by Carla Avesani on the nutritional blog. In the nutritional blog you will also have the opportunity to provide the readers your comments and thoughts about the interesting study by Moosa Salehi et al. on the effects of selenium supplementation on nutritional status in HD-patients.

Enjoy your NDT-E
Peter Stenvinkel, Editor-in-chief