Editorial issue 247

Dietary phosphorus is associated with greater left ventricular mass

In the 247th issue of NDT-E you will find several novel interesting papers to read. In a paper recently published in Kidney International, Dr. Kalani Yamamoto et al. showed in 4,494 participants from the Multi-Ethnic Study of Atherosclerosis that higher dietary phosphorus intake was associated with greater odds of left ventricular mass among women, but not men. In another interesting paper recently published in Kidney Int, John David Spencer et al. show that RNase 7 expression is increased in the urinary tract with infection and has antibacterial activity against uropathogens at micromolar concentrations. In a mini review published in Kidney Int Anna Jovanovich and Tomas Berl discuss where vaptans do and do not fit in the treatment of hyponatremia. In a recent paper published in NDT Liesbeth Viaene et al. show that high circulating sclerostin levels are associated with improved survival and suggest that a low bone-specific alkaline phosphatase activity may be in the causal pathway. In another NDT paper Francesco Locatelli et al. demonstrate that colestilan (a non-absorbed, non-calcium-based, phosphate binder) is an effective treatment for hyperphosphataemia, and provides beneficial effects on other metabolic parameters associated with cardiovascular risk, notably LDL-C. Finally, Charles Chazot et al. discuss thrice-weekly nocturnal hemodialysis as an overlooked alternative to improve patient outcomes.

In this issue of NDT-E you will also find four CME lectures presented at the ERA-EDTA meeting in Paris May 2012. Dr. Peter W. de Leeuw, Maastricht, Netherlands presents an interesting lecture entitled “PATHOPHYSIOLOGICAL RENAL CHARACTERISTICS OF PREHYPERTENSION”. The 2nd lecture is entitled ”TUBULO-INTERSTITIAL CHANGES IN EARLY HYPERTENSION AND ITS RELATION TO NATRIURESIS” and is presented by Dr. Jacek Manitius, Bydgoszcz, Poland. The 3rd lecture by Dr. Alexander Rosenkranz, Graz, Austria, Germany will present information on ”EARLY MARKERS OF RENAL DYSFUNCTION IN PREHYPERTENSION”. The final CME lecture is presented by Dr. Luis Ruilope, Madrid, Spain, Netherlands and is entitled ”CHRONIC KIDNEY DISEASE AND PREHYPERTENSION”.

In this issue of NDT-E you can also do the novel bone survey with two parts; one testing your knowledge about this adynamic bone disease and one practice pattern part.

Enjoy your NDT-E

Peter Stenvinkel, Editor-in-chief