Editorial issue 250

Editorial 250th issue of NDT-Educational

This is the 250th issue of NDT-educational. Having been recently asked by the ERA-EDTA council to become the Editor in chief of NDT edu., I would like, at the onset of this transition, to pay a tribute to my predecessors . Professor Carmine Zoccali, before becoming the Editor in Chief of NDT, had the vision to develop this modern tool for the nephrology community, that rapidly received much attention. He was followed by Professor Peter Stenvinkel who succeeded in developing further the many facets of NDT edu. I will do my best to work along the same lines, in collaboration with the many other resources offered by ERA-EDTA to members.


Obviously, NDT Edu is not only the job of the Editor in chief, but rather a team work, with most importantly the webmaster Francesca Trebelli , and others at ERA-EDTA office , who are doing a great job to make it all possible. Finally the Board of NDT edu also plays an important role in reviewing papers, proposing topics or surveys etc. …


This 250th issue of NDT Edu contains some important papers for your consideration. In a paper recently published in Kidney International (KI), Paul et al. (Mayo Clinic , USA) report that reanalysis of the few published families without apparent linkage of ADPKD to  PKD1 and PKD2, does not support the existence of a third gene (“PKD3”). In fact, they discovered some false positive diagnosis by ultrasound, blurring the linkage analysis. This has now been resolved by direct mutation screening.  In another interesting KI paper, Ravani et al. report their results with rituximab in 46 consecutive children with steroid-dependent and calcineurin inhibitor-dependent idiopathic nephrotic syndrome in an Italian collaborative study. Monteiro et al. (Paris, France), in a third KI paper, found in a short-term human study evidence for impaired tissue kallikrein stimulation by a low sodium/high potassium diet in subjects with the R53H loss of function polymorphism of human tissue kallikrein. This points to inappropriate renal adaptation to a potassium load. You will also find an interesting review , just published in NDT by Muthalaggapan et al.(London, UK), entitled ”Dialysis or conservative care for frail older patients: ethics of shared decision-making?”.


Finally, a last paper just published in  J Clin Invest by Zhou et al. (Kansas City, USA), points to a potential role for sirtuin inhibition as a way to delay cyst formation in ADPKD again. Using among others knock-out models , they conclude that sirtuin 1, a member of the sirtuin family of NAD (Nicotinamide-Adenine Dinucleotide )-dependent tissue deacetylases, plays a role in cyst formation. They further show that sirtuin 1 can be inhibited by several agents, including the old Nicotinamide and that this inhibition indeed delays cyst formation.


In this issue of NDT-E you will also find four CME lectures presented at the ERA-EDTA meeting in Paris May 2012. All of them deal with the topic of bone and mineral disorders. Dr. Teresa Adragao, from Cascais, Portugal, first presents a lecture entitled “VASCULAR CALCIFICATION IN PATIENTS WITH CKD. OUTCOMES AND THERAPY”. The 2nd lecture is entitled “MAGNESIUM AND CARDIOVASCULAR DISEASE IN CKD” and is presented by Dr. Fatih Kircelli, from Yozgat, Turkey. The 3rd lecture by Dr. Patrick D’Haese , is entitled “VASCULAR CALCIFICATIONS – LESSONS FROM ANIMAL STUDIES”. The final one is presented by Dr. Andreas Pasch, Bern, Switzerland and is entitled “ THE MYSTERIOUS EFFECTS OF SODIUM THIOSULFATE ON EXTRAOSSEOUS CALCIFICATIONS”.


Lastly, we want to hear from you:  the aim of NDT edu is to help ERA-EDTA members, mostly nephrologists, in their daily job(s). Should you have any suggestions for further developments, we realize the IT world is changing rapidly, do not hesitate to contact us at editor@ndt-educational.org, we will carefully consider your suggestions and hopefully be able to implement at least some of them.


Enjoy NDT edu


Michel Jadoul

Editor-in-Chief NDT-Educational