Editorial issue 259

In the first paper selected for this 259th issue of NDT-Edu, Ashraf S. et al report in the Journal  of Clinical Investigation (November 2013) that ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. This elegant work relying on exome sequencing may point to Coenzyme Q10 supplementation as a treatment of some cases of steroid-resistant nephrotic syndrome. In the second paper, G. MjØen et al report in Kidney International (November 2013) a study from Norway on the long-term risks for kidney donors. No doubt this paper will raise substantial discussion on an important topic. In the third paper, again in Kidney International (November 2013), A. Levin A. and P. E. Stevens, the co-chairs of the recent KDIGO CKD Guideline Summarize the content of that guideline :” KDIGO 2012 CKD Guideline : behind the scenes, need for guidance, and a framework for moving forward”. In the fourth paper, Delmas Y. et al report in the November issue of NDT their experience during an outbreak of Escherichia coli 0104 :H4 haemolytic uraemic syndrome in France , and especially the outcome with eculizumab. Finally, J. Hare  et al., again  in NDT, publish a small-sized pilot randomized controlled trial designed to evaluate the effectiveness of a cognitive behavioural group approach to improve patient adherence to peritoneal dialysis fluid restrictions.

The CME lectures of this 259Th issue, all from the recent Istanbul ERA-EDTA Congress,  deal with 2 long-term “friends” (sometimes) or enemies (mostly) of nephrologists: salt and uric acid. In the first one, Prof. Luca de Nicola (Naples, Italy) discusses why regarding “ Low sodium diet in CKD patients : it’s time for action!”. In the second one, Prof. Yunus Erdem (Ankara, Turkey) presents “Salt as an addictive compound : central mechanisms of salt addiction”. In the third one, Prof. Jens Titze (Nashville, USA) reviews recent groundbreaking data on “Sodium storage in ESRD patients”.

In the fourth lecture Prof. Gerjan Navis (Groningen, the Netherlands) reviews the “ Genetic Epidemiology of hyperuricemia”. Finally, Dr Mehmet Kanbay (Istanbul, Turkey) discusses “The role of uric acid in the progression of CKD”.


Enjoy NDT-Educational


Prof. Michel Jadoul

Editor-in-Chief NDT-Educational