Why kidney disease damages the vascular system

Modified "good" cholesterol (HDL) and the activation of specific genes are causes of damage to the vascular system in chronic renal disease. These fundamental findings are the result of a recently completed project supported by the Austrian Science Fund FWF and could facilitate new approaches to prevention. The project specifically examined the effect of cyanate, a decomposition product of urea, on the functioning of the vascular system.

Patients suffering from chronic renal disease frequently die from cardiovascular complications. A damaged and poorly functioning vascular system is the reason for such complications. A team working with Gunther Marsche at the Medical University of Graz on a project supported by the FWF investigated the extent to which a specific decomposition product (cyanate) of urea, which occurs in a concentrated form in the blood of patients with renal disease, is responsible.


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