Transplant Recipients At Increased Risk When Low Levels Of Donor-Specific Antibodies Present

Findings could help provide better donor-recipient matches and tailor recipients' treatments after kidney transplantation 


  • The detection of preformed donor-specific antibodies by newer tests, despite negative results from traditional tests, nearly doubles a kidney transplant recipient's risk for rejection.
  • It also increases the risk of kidney failure by 76%.
    Nearly 17,000 kidney transplants take place each year in the United States.

Kidney transplant recipients who have even very low levels of preformed antibodies directed against a donated kidney have a significantly increased risk of organ rejection and kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings could help clinicians provide better donor-recipient matches and tailor recipients' immunosuppressive therapy after transplantation.

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