NDT-EDUCATIONAL

In Pediatric Kidney Transplant Recipients, Antibody Response Linked With Rejection

A transplanted kidney has a finite life expectancy because it often becomes the target of the recipient's immune system, which may mount antibodies that attack the organ. Because there is a critical need to extend the life of transplanted organs - especially in children, who can face two to three kidney transplants in their lifetime - researchers recently examined the role of this antibody-mediated injury in rejection and the effectiveness of medications to prevent it. Their findings are reported in the Journal of the American Society of Nephrology (JASN).


Minnie Sarwal, MD, FRCP, PhD (California Pacific Medical Center) and her colleagues mapped the antibody immune response in 130 children who received kidney transplants through 12 different US transplant programs participating in a trial comparing complete steroid avoidance after transplantation and standard steroid therapy after transplantation. (Some patients received long-term steroids after transplantation as a treatment to potentially protect the new organ from antibody-mediated injury, while others received no steroids.) Patients were monitored for two years after transplantation.

 

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