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In mouse model of diabetic kidney disease, enzyme restores function

Researchers at the University of California, San Diego School of Medicine say that, while a prevailing theory suggests elevated cellular levels of glucose ultimately result in diabetic kidney disease, the truth may, in fact, be quite the opposite. The findings could fundamentally change understanding of how diabetes-related diseases develop - and how they might be better treated.

 

Writing in the Journal of Clinical Investigation, Kumar Sharma, MD, professor of medicine and director of the Center for Renal Translational Medicine (CRTM) at UC San Diego, Laura Dugan, MD, professor of medicine and Larry L. Hillblom Chair in geriatric medicine, Young You, PhD (CRTM), Robert Naviaux, MD, PhD, professor of medicine, and colleagues describe first-ever studies of real-time superoxide production in the kidneys of live mice with type 1 diabetes.

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