Editorials

Editorial Issue 223

Resveratrol improves renal microcirculation

In the 223rd issue of NDT-E you will find a series of interesting novel full papers that may increase your knowledge in nephrology. In the first full paper, published in J Clin Invest, Britta George et al. present observations suggesting that activation of a Cas-Crk1/2–dependent complex is necessary for foot process effacement observed in distinct subsets of human glomerular diseases. In another interesting full paper published in J Clin Invest, Eric Berglund et al. demonstrate that direct leptin action on proopiomelanocortin neurons does not reduce food intake, but is sufficient to normalize glucose and glucagon levels in mice otherwise lacking leptin receptor.

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Editorial Issue 222

Learn more about iga nephropathy in this issue of NDT-Educational

In the 222nd issue of NDT-E you will find four interesting CME lectures presented at the ERA-EDTA meeting in Prague June 2011. In the first lecture Dr Rosanna Coppo, Turin, Italy presents an update on “IS A LEGACY EFFECT POSSIBLE FOR IGA NEPHROPATHY?” She concludes her talk by stating that we should consider early treatment before a no-return phase of the immune committment. Moreover, the renal community should search for new drugs targeting the mucosal immunity with little systemic effect in IGAN.Finally, we should focus future reserach on potentiating the recovery capacity and investigate the possibility of increasing T reg cell activity. The second talk is entitled ” GENOMICS IN IGA NEPHROPATHY” and is presented by Dr Francesco Paolo Schena, Bari, Italy. The 3rd talk discusses ”RECURRENCE OF IGA NEPHROPATHY AFTER KIDNEY TRANSPLANTATION” and is presented by Dr Jürgen Floege, Aachen, Germany. In this talk Dr Floege tells us that recurrent IgAN results in graft failure in 8-23% and graft loss in about 1-16% of the patients at 5-6 years. In the final talk Dr Ian Roberts, Oxford, UK will discuss ”HISTOLOGIC MARKERS INDICATING THE NEED FOR THERAPEUTIC INTERVENTION IN IGA NEPHROPATHY”.

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Editorial Issue 221

New data show that obesity is associated with hypothalamic injury in both rodents and humans

In the 221th issue of NDT-E you will find three CME lectures presented at the ERA-EDTA meeting in Prague June 2011. In the first lecture Peter Barany, Stockholm, Sweden will present an update on “ADIPOKINE SIGNALING AND THE KIDNEY”. The second talk is entitled ”METABOLIC ROLE OF NATRIURETIC PEPTIDE – IS IT IMPORTANT FOR RENAL FAILURE?” and is presented by Max Lafontan, Toulouse, France. The last talk will discuss ”VASOPRESSIN AS A RISK FACTOR FOR CKD” and is presented by Ron T. Gansevoort, Groningen, Netherlands. In his talk Dr Gansevoortconcludes that both observational and interventional data support a role for vasopressin as a risk factor for progressive CKD. Moreover, future studies will need to test various interventions to block vasopressin activity. In the field of adult polycystic kidney disease there are two randomised controlled trials underway.

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Editorial Issue 220

Pleiotrophin triggers inflammation and lead to peritoneal fibrosis

In the 220^th issue of NDT-E you will find a series of interesting novel papers that undoubtedly will increase your knowledge in nephrology. In the first full paper, published in Kidney Int, Hideki Yokoi et al used microarray analysis and compared gene expression profiles of the peritoneum in control and chlorhexidine gluconate-induced peritoneal fibrosis in mice.

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