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Registered
Charity No. 1060134 |
| CME Course on Basic science and Clinical Nephrology |
| (6 Italian EMC credits) |
Molecular mechanisms in the pathogenesis of renal diseases
as targets for new therapies
March 18-19, 2005
Villa Gualino, Turin, Italy
SCIENTIFIC PROGRAMME
| Friday, March 18, 2005 |
| 14.15 – 14.30 |
| Greetings - F. Locatelli, ERA-EDTA President (Lecco, Italy) |
| Aim of the Course - R. Coppo (Turin, Italy) |
| Chairman: F.P. Schena (Bari, Italy) |
| 14.00 - 15.00 |
| Lecture: |
| Monocyte- macrofages induced renal damage and ways to blunt their harmful effects - A. Rees (Aberdeen, United Kingdom) |
Further insight |
T. Rampino (Pavia, Italy): Pathogenic Role of Macrophage Stimulating Protein in anti-Thy 1 nephritis |
E. Menegatti (Turin, Italy): Mycophenolate in anti Thy1 nephritis |
A. Pani (Cagliari, Italy): Plasma exchange in cryoglobulinaemia: is it worthwile? |
| Discussion |
| 15.30 - 16.30 |
| Lecture: |
| Proliferation: inflammation but also renal repair - P. Mené (Rome, Italy) |
| Further insight |
B. Bussolati (Turin, Italy): Isolation of progenitor cells from adult human kidney. |
MP. Rastaldi (Milan, Italy): Glomerular oxidative damage and podocyte alterations in type II diabetic nephropathy |
D. Mancuso (Padua, Italy): Effects of different doses of steroids on interaction between human endothelial cells and lymphomonocytes. |
| Discussion |
| 16.30 - 17.30 |
| Lecture: |
| Apoptosis: limitation of inflammation but also cell loss – A. Amore (Turin, Italy) |
| Further insight |
| F. Mariano (Turin, Italy): Role of apoptosis in sepsis –associated acute renal failure |
C. Lorz (Madrid, Spain): Apoptosis gene expression analysis: identification of predictors of renal injury and potential targets |
R. Polci (San Antonio, USA): Apoptosis and polycystic kidney: role of protein kinase NEK1 |
| Discussion |
| 17.30 - 18.30 |
| Lecture: Matrix metalloproteases in disease progression and repair: the two faces of the coin - P. Ronco (Paris, France) |
| Further insight |
C. Chatziantoniou (Paris, France): Effect of metalloproteinase-9 deficiency on the vascular wall |
JJ. Boffa (Paris, France): Metalloproteases and regression of fibrosis: which role do they play? |
C. Esposito (Naples, Italy): Modulation of extracellular matrix turn-over: role of genetic background |
| Discussion |
| Saturday, March 19, 2005 |
| Chairman: A. Dal Canton (Pavia, Italy) |
| 8.00 – 9.00 |
| Lecture: |
| Activation of transcription factors in glomerular diseases and inhibition therapies - R. Coppo (Turin, Italy) |
| Further insight |
C. Gòmez Guerrero (Madrid, Spain): Natural products inhibit NF-kB-mediated inflammation during renal and vascular damage |
A. Onetti-Muda (Rome, Italy): Confocal microscopy as a new tool to investigate transcription factors |
L. Peruzzi (Turin, Italy): Immunoproteasome in IgA nephropathy |
R. Bertelli (Genoa, Italy): Transcriptional factors for regulation of podocin expression in podocytes |
| Discussion |
| 9.00 – 10.00 |
| Lecture: |
| PGDF: its role in glomerular diseases and the ways to inhibit it - J. Floege (Aachen, Germany) |
| Further insight |
P. Mertens (Aachen, Germany): Hunting for a PDGF-B dependent transcriptional regulator |
T. Ostendorf (Aachen, Germany): VEGF and glomerular angiogenesis |
| Discussion |
| 10.30 - 11.30 |
| Lecture: |
RAS: mechanisms of perpetuate renal damage and optimization of the treatment approaches – J. Egido (Madrid, Spain) |
| Further insight |
G. Gambaro (Verona, Italy): Inhibition of the TGFß-1 gene: the glycosaminoglycan story |
| Discussion |
| 11.30 - 12.30 |
| Lecture: |
| The role of proximal tubular cells-T lymphocytes interaction in the pathogenesis of renal fibrosis – L. Gesualdo (Foggia, Italy) |
| Further insight |
G. Grandaliano (Bari, Italy): Protease-activated receptors and renal fibrosis |
F. Anglani (Padua, Italy): Looking at the plasticity of renal tubular cells: mRNA profiling of the epithelial-mesenchymal transition induced by TGFß1 in HUTEC in primary culture |
| Discussion |
| 12.30 - 13.30 |
| Lecture: |
| Role of stem cell in renal repair and in microchimerism of transplanted organs – G. Camussi (Turin, Italy) |
| Further insight |
E. Bertoni (Florence, Italy): High pre-transplant CXCL10 serum levels are related to increased risk of allograft failure:histopathological and clinical aspects |
G. Conti (Turin, Italy): P-glycoprotein activity in transplantation. |
L. Del Prete (Padua, Italy): TGFß1 and BMP-7 in kidney transplant: expression study in serial and protocol biopsies. |
| Discussion |