European Training Centres

Peer Reviewed Publications in International Journals (only English) 2000-2003

Publications list

2003

Williams JM, Ben-Smith A, Hewins P*, Dove SK, Hughes P, McEwan R, Wakelam MJ*, Savage CO*. Activation of the G(i) Heterotrimeric G Protein by ANCA IgG F(ab')(2) Fragments Is Necessary but not Sufficient to Stimulate the Recruitment of Those Downstream Mediators Used by Intact ANCA IgG. Journal of the American Society of Nephrology 2003; 14(3): 661-9

Sharif K, Beath SV, Kelly DA*, McKiernan P, Van Mourik I, Mirza D*, Mayer AD*, Buckels JA*, De Ville De Goyet J. New perspective for the management of near-total or total intestinal aganglionosis in infants. J Pediatr Surg 2003; 38(1): 25-8

Hewins P*, Savage C*. Anti-neutrophil cytoplasm antibody associated vasculitis. International Journal of Biochemistry and Cell Biology 2003; 35(3): 277-82

2002

Cooper JC, Hughes S, Ben-smith A, Savage COS*, Winer JB*. T cell recognition of a non-protein antigen preparation of Campylobacter jejuni in patients with Guillain-Barre syndrome. Journal of Neurology, Neurosurgery and Psychiatry 2002; 72: 413-414

Kamesh L*, Harper L*, Savage CO*. ANCA-Positive Vasculitis.. Journal of the American Society of Nephrology 2002; 13(7): 1953-60

Howie AJ*, Buist LJ*, Coulthard MG. Reflux nephropathy in transplants. Pediatric Nephrology 2002; 17(7): 485-90

Beath S, de Ville de Goyet J, Kelly D*, McKiernan P, Buckels J*, Mirza D*, Mayer A*. Induction therapy for small bowel transplant recipients: early experience in Birmingham, UK. Transplantation Proceedings 2002; 34(5): 1892

Mayer A*. Chronic rejection and graft half-life: five-year follow-up of the European Tacrolimus Multicentre renal study. Transplantation Proceedings 2002; 34(5): 1491

Ray S, Samuel T*, Hawker J, Smith S*. Hepatitis B immunisation in renal units in the United Kingdom: questionnaire study. BMJ 2002; 324(7342): 877-8

Winer J*, Hughes S, Cooper J*, Ben-Smith A, Savage C*. gamma delta T cells infiltrating sensory nerve biopsies from patients with inflammatory neuropathy. Journal of Neurology 2002; 249(5): 616-21

Cockwell P*, Calderwood JW, Brooks CJ, Chakravorty SJ, Savage CO*. Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines. Nephrology, Dialysis, Transplantation 2002; 17(5): 734-44

Zehnder D*, Bland R, Chana RS*, Wheeler DC*, Howie AJ*, Williams MC, Stewart PM*, Hewison M. Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion. Journal of the American Society of Nephrology 2002; 13(3): 621-9

Cockwell P*, Chakravorty SJ, Girdlestone J, Savage CO*. Fractalkine expression in human renal inflammation. Journal of Pathology 2002; 196(1): 85-90

Samuel T*, Cockwell P*. Islet cell transplantation. Journal of the Royal Society of Medicine 2002; 95(1): 31-3

Benson SR, Ready AR*, Savage CO*. Donor platelet and leukocyte load identify renal allografts at an increased risk of acute rejection. TRANSPLANTATION 2002; 73(1): 93-100

Harper L*, Nuttall SL, Martin U*, Savage CO*. Adjuvant treatment of patients with antineutrophil cytoplasmic antibody-associated vasculitis with vitamins E and C reduces superoxide production by neutrophils. Rheumatology (Oxford) 2002; 41(3): 274-278

Savage CO*. The evolving pathogenesis of systemic vasculitis. Clin Med 2002; 2(5): 458-64

Tauro S, Clark FJ*, Duncan N*, Lipkin G*, Richards N*, Mahendra P*. Recovery of renal function after autologous stem cell transplantation in myeloma patients with end-stage renal failure. Bone Marrow Transplantation 2002; 30(7): 471-3

Eardley KS*, Wan DI, Thomas ME, Banerjee AK, Radojkovic M, Taylor JL. Transplant-associated inflammatory breast disease. Nephrology, Dialysis, Transplantation 2002; 17(3): 512-5

Inston NG*, Cockwell P*. The evolving role of chemokines and their receptors in acute allograft rejection. Nephrology, Dialysis, Transplantation 2002; 17(8): 1374-9

Chakravorty SJ, Cockwell P*, Girdlestone J, Brooks CJ, Savage CO*. Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion. Clinical and Experimental Immunology 2002; 129(1): 150-9

Holland M, Takada K, Okumoto T, Takahashi N, Kato K, Adu D*, Ben-Smith A, Harper L*, Savage CO*, Jefferis R. Hypogalactosylation of serum IgG in patients with ANCA-associated systemic vasculitis. Clinical and Experimental Immunology 2002; 129(1): 183-90

Brooks S, Morgan M*. Accuracy of clinical diagnosis in knee arthroscopy. Annals of the Royal College of Surgeons of England 2002; 84(4): 265-8

Savage CO*, Harper L*, Holland M. New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis. Current Opinion in Rheumatology 2002; 14(1): 15-22

Eardley KS*, Jones HE, Osman H*, Smith SA*. Efficacy of the accelerated hepatitis B vaccination schedule used in haemodialysis patients post-exposure to virus: a single-centre experience. Nephrology, Dialysis, Transplantation 2002; 17(11): 1982-7

2001

Balding CE, Howie AJ*, Drake-Lee AB*, Savage CO*. Th2 dominance in nasal mucosa in patients with Wegener's granulomatosis.. Clinical and Experimental Immunology 2001; 125(2): 332-339

Landray MJ*, Thambyrajah J, McGlynn FJ*, Jones HJ, Baigent C, Kendall MJ*, Townend JN*, Wheeler DC*. Epidemiological evaluation of known and suspected cardiovascular risk factors in chronic renal impairment. American Journal of Kidney Diseases 2001; 38(3): 537-546

De groot K, Adu D*, Savage COS*. The value of pulse cyclophosphamide in ANCA-associated vasculitis. Metanalysis and critical review. Nephrology, Dialysis, Transplantation 2001; 16: 2018-2027

Day C, Savage COS*, Jones EL*, Cockwell P*. Henoch-Schonlein nephritis and non-Hodgkin's lymphoma. Nephrology, Dialysis, Transplantation 2001; 16: 1080-1081

Adu D*, Cross J, Jayne DR. Treatment of systemic lupus erythematosus with mycophenolate mofetil. LUPUS 2001; 10(3): 203-208

Harper L*, Radford D, Plant T, Drayson M*, Adu D*, Savage CO*. IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytosplasmic antibody-positive patients. Arthritis and Rheumatism 2001; 44(4): 921-930

Howie AJ*, Ferreira MA, Adu D*. Prognostic value of simple measurement of chronic damage in renal biopsy specimens. Nephrology, Dialysis, Transplantation 2001; 16(6): 1163-1169

Harper L*, Cockwell P*, Adu D*, Savage CO*. Neutrophil priming and apoptosis in anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Kidney International 2001; 59(5): 1729-1738

Thambyrajah J, Landray MJ*, Jones HJ, McGlynn FJ*, Wheeler DC*, Townend JN*. A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease. Journal of the American College of Cardiology 2001; 37(7): 1858-1863

Radford DJ, Luu NT, Hewins P*, Nash GB*, Savage CO*. Antineutrophil cytoplasmic antibodies stabilize adhesion and promote migration of flowing neutrophils on endothelial cells. Arthritis and Rheumatism 2001; 44(12): 2851-61

Chakravorty SJ, Howie AJ*, Girdlestone J, Gentle D, Savage CO*. Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation. Journal of Pathology 2001; 194(2): 239-246

Adu D*. The evidence base for the treatment of lupus nephritis in the new millennium. Nephrology, Dialysis, Transplantation 2001; 16(8): 1536-1538

Tse WY, Williams J, Pall A, Wilkes M*, Savage CO*, Adu D*. Antineutrophil cytoplasm antibody-induced neutrophil nitric oxide production is nitric oxide synthase independent. Kidney International 2001; 59(2): 593-600

Dmitrewski J*, Krentz AJ, Mayer AD*, Buckels JA*, Barnes AD*, Smith J, Nattrass M*. Metabolic and hormonal effects of tacrolimus (FK506) or cyclosporin immunosuppression following renal transplantation. Diabetes Obes Metab 2001; 3(4): 287-292

Harper L*, Savage CO*. Leukocyte-endothelial interactions in antineutrophil cytoplasmic antibody-associated systemic vasculitis. Rheumatic Diseases Clinics of North America 2001; 27(4): 887-903

Eardley KS*, Raza K, Adu D*, Situnayake RD. Gold treatment, nephrotic syndrome, and multi-organ failure in a patient with adult onset Still's disease. Annals of the Rheumatic Diseases 2001; 60(1): 37015-

Savage CO*. ANCA-associated renal vasculitis. Kidney International 2001; 60(4): 1614-27

Pal BR, Preston PR, Morgan ME*, Rushton DI, Durbin GM. Frontal horn thin walled cysts in pre-term neonates are benign. Archives of Disease in Childhood. Fetal and Neonatal Edition 2001; 85(3): F187-93

Ben-Smith A, Dove SK, Martin A, Wakelam MJ*, Savage CO*. Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation. BLOOD 2001; 98(5): 1448-1455

European Fellows programme

Specify if the Unit accepts fellows from European countries for:
Short (1-2 month) well focused training programs either clinically or laboratory oriented: Not usually.
Long (at least 1 year) research fellowships: Yes subject to funding availabilty.
Specify corresponding availability of grants: No.
Specify if the Unit may provide help for accommodation: Yes.

Prerequisites for Fellowship

Language: English

Work/Research experience: Experience equivalent to MRCP part 2 for clinical studies/laboratory experience desirable for research studies.

HEAD OF THE UNIT	Prof C. Savage, Dr G. Lipkin
CLINICAL STAFF	Dr D ADU Consultant Physician & Nephrologist Dr S BALL Consultant Physician & Nephrologist Dr P COCKWELL Consultant Physician & Nephrologist Dr C FERRO Consultant Physician & Nephrologist Dr L FOGGENSTEINER Consultant Physician & Nephrologist Dr L HARPER Senior Lecturer in Nephrology Dr G LIPKIN Consultant Physician & Nephrologist Dr N T RICHARDS Consultant Physician & Nephrologist Professor C SAVAGE Professor of Nephrology Professor/Colonel M WORLD Professor of Military Medicine Mr A READY Consultant Surgeon Mr L C TAN Consultant Surgeon Mr M OMAR Locum Consultant Surgeon
RESEARCH STAFF	Dr R BATES Research Fellow Miss J CALDERWOOD PhD Student Miss R COLMAN Technician Dr C DAY Clinical Research Fellow Dr K EARDLEY Clinical Research Fellow Dr A EL-MEDHEM Clinical Research Fellow Dr P HEWINS Clinical Research Fellow Dr N INSTIN Clinical Research Fellow Dr L KAMESH Clinical Research Fellow Dr M MORGAN Clinical Research Fellow Dr S JOHNSON SpR (Paediatric) Dr J HOLLE Post-Doc Research Fellow Dr X LU Post-Doc Research Fellow Dr J Williams Senior Non-Clinical Research Fellow

CONTACT INFORMATION
E-MAIL	Bindu.Gohil@uhb.nhs.uk
PHONE:	+44-121-4721311
FAX:	+44-121-6272527
FULL POSTAL ADDRESS	University Hospital Birmingham Nhs Trust, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK
WEBSITE OF THE UNIT	www.uhb.nhs.uk

CLINICAL FACILITIES
NEPHROLOGY BEDS N°	54
HEMODIALYSIS PATIENTS N°	736 (March 2003)
PERITONEAL DIALYSIS PATIENTS N°	163 (March 2003)
INTENSIVE CARE NEPHROLOGY BEDS N°	6 (acute renal failure)
RENAL TRANSPLANTS /YEAR (2002) N°	130 (April 2002)


University of Birmingham	Queen Elizabeth Hospital