EUROPEAN TRAINING CENTRES

bologna
Bologna
malpighi
Dipartimento di Medicina Interna, dell’Invecchiamento e Malattie Nefrologiche; Policlinico S.Orsola-Malpighi
             

Bologna, Italy

 

 

 

HEAD OF THE UNIT Antonio Santoro
CLINICAL STAFF

L. B. De Sanctis; A. Di Felice;  M. G. Facchini; E. Ferramosca; R. Gaggi; A. Lopez; E. Mambelli; E. Mancini; M. Mandreoli; S. Pasquali; E. Sestigiani; A. Zucchelli ; L. Soverini; C. Cannarile (fellow); M. Flachi (fellow); G. Ubaldi (fellow).
RESEARCH AND LABORATORY
E. Ferramosca, S. Pasquali, M. Mandreoli,  E. Mancini
 

 

CONTACT INFORMATION
NAME OF THE UNIT
Unità Operativa Nefrologia Dialisi Ipertensione
E-MAIL nephro.dir@aosp.bo.it
PHONE: + 39 051 636 2430
FAX: + 39 051 636 2511
FULL POSTAL ADDRESS via P. Palagi 9 ; 40138 Bologna (Italy)
WEBSITE OF THE UNIT
http://nephro-malpighi.com

 

CLINICAL FACILITIES
NEPHROLOGY BEDS N° 25
HEMODIALYSIS PATIENTS N° 227
PERITONEAL DIALYSIS PATIENTS N° 31
INTENSIVE CARE NEPHROLOGY BEDS N° 2
RENAL TRANSPLANTS /YEAR (2006) N° 14

 

RESEARCH INTERESTS

RESEARCH PROGRAMS
 
• Regional (Emilia-Romagna) project about Chronic Kidney Disease (population study and registry)
• Renal involvement and renal pathology in:
  rare diseases (Vasculitis,  Alport’s syndrome, medullary cystic disease, von Hippel Lindau);
  hematologic diseases (multiple myeloma, leukemia, amyloidosis, cryoglobulinemia);
  systemic diseases (LES, rheumatoid arthritis ...);
  patients with non-renal organ transplantation (liver, myocardial, bone marrow).
   
• Prevention of the progression of renal diseases, with particular concern to diabetes mellitus
   

• Ischemic nephropathy
   
• The cardiovascular damage in patients with renal failure:
  arterial stiffness assessment by pulse wave velocity measurement;
 

carotid intima-media thickness measurement by b-mode ultrasound scan;
  left ventricular hypertrophy assessed by echocardiography.
   
• Prevention of cardiovascular instability in hemodialysis: uninvasive monitoring and automatic control systems
   
• New dialysis technlologies
   
• Electronic systems for remote control of dialysis
   
• Acute renal failure in the critically ill patients
   
• Extracoporeal support and new systems for blood purification in patients with non-renal organ failure (liver, heart)
   
   
PROJECTS LIST
   
• Study of the glomerular permeability in patients with glomerulosclerosis
   
• The use of athorvastatin in chronic renal failure: observational study of mortality and morbidity in patients with pre-end stage chronic renal failure
   
• The use of a renin inhibitor in slowing the progression of renal damage in type II diabetes
   
• Evaluation of the efficacy of new forms of erythropoietin (pegylated) in the dialysis patients
   
• Efficacy of a recently developed artificial liver system for blood purification and dialysis in patients with acute-on-chronic hepatic failure and associated renal failure  
   
• Efficacy of erythropoietin therapy in the recovery of acute renal failure
   
• Efficacy of  periodical ultrafiltration treatment in diuretic non-responder heart failure
   
• Use of intradialytic parenteral nutritional supplementation in the malnutrition state in dialysis patients: effects on the biochemical and  clinical parameters (hospitalization, outcome)
   
• Evaluation of nutritional, inflammatory, cardiovascular parameters and depurative efficacy of mid-dilution, a new  hemodiafiltration technique.  
   
• Blood purification techniques in the extracorporeal support of sepsis
   
• The treatment of secondary hyperparathyroidism with new pharmacological options
   

Peer Reviewed Publications in International Journals (only English) 2000-2006

Santoro A, Mancini E, Zucchelli P. The impact of hemofiltration on the systemic cardiovascular response. Nephrol Dial Transplant 2000;15(Suppl 2): 49-54
Severi S, Cavalcanti S, Mancini E, Santoro A. Heart rate response to hemodialysis-induced changes in potassium and calcium levels. J Nephrol 2001; 14:488-496.
Arrigo G, Tetta C, Santoro A, Ghezzi P et al. Continuous urea monitoring in hemodialysis: a model approach to forecast dialytic performance. Results of a multicenter study. J Nephrol 2001; 14:481-487.
Severi S, Cavalcanti S, Mancini E, Santoro A. Effect of electrolyte and pH changes on the sinus node pacemaking in humans. J Electrocardiol 2002;35(2) 115-124.
Cavalcanti S, Cavani S, Santoro A. Role of short term regulatory mechanisms on pressure response to hemodialysis-induced hypovolemia. Kidney Int 2002;61:228-238.
Cirignotta F, Mondini S, Santoro A, Ferrari G et al. Reliability of a questionnaire screening restless legs syndrome in patients on chronic dialysis. Am J Kidney Dis 2002; 40:302-306.
Santoro A, Mancini E. Cardiac effects of chronic inflammation in dialysis patients. Nephrol Dial Transplant 2002;17(Suppl 8):10-15.
Santoro A, Mancini E, Basile C, Amoroso L et al. Blood-volume controlled hemodialysis in hypotension-prone patients: a randomised, multicenter, controlled trial. Kidney Int 2002; 62:1034-1045.
Maggiore Q, Pizzarelli F, Santoro A, Panzetta G et al. The effect of control of thermal balance on vascular stability in hemodialysis patients: results of the European randomized clinical trial. Am J Kidney Dis 2002;40(2):280-290.
Mandreoli M, Casanova S, Vianelli N, Pasquali S, Zucchelli P. Remission of nephrotic syndrome due to AA amylodosis and initiation of glomerular repair after surgical resection of localized Castelman’s disease. Nephron 2002;90:336-340.

B. Polasco, P. Altieri, S. Andrulli, C. Basile, S. Di Filippo, M. Feriani, L. Pedrini, C. Zoccali, A.Santoro, G.Sau, F. Locatelli
Convection versus diffusion in dialysis: an Italian  prospective multicenter study
Nephrol Dialysis Transplant 2003;18 (Suppl. 7): vii 50- vii 54     

A. Santoro, E. Mancini, E. Mambelli, C. Canova
Thermal balance in convective therapies
Nephrol Dial Transplant, 2003; 18 (Suppl. 7): vii 41-vii 45

S. Severi, S. Vecchietti, S. Cavalcanti, E. Mancini, A. Santoro
Electrocardiographic changes during haemodiafiltration with different potassium removal Rates
Blood Purif 2003;21:381-388

A. Santoro, E. Mambelli, C. Canova, A. Lopez, E. Sestigiani, E. Mancini
Biofeedback in dialysis
J  Nephrol 2003;16 (S7): 48-56

C. Pozzi, M. D’Amico, GB Fogazzi, S. Curioni, F. Ferrario, S. Pasquali et al.
Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors
Am J Kidney Dis 2003;42(6):1154-1163

A. Santoro, C. Canova, E. Mancini, R. Deppisch, W. Beck
Protein loss in on-line Hemofiltration
Blood Purif 2004 22:261-268

S. Cavalcanti, A. Ciandrini, S. S. Severi, F. Badiali, S. Bini, A. Gattini, L. Cagnoli, A. Santoro
Model- based study on the effects of the haemodialysis technique on the compensatory response to hypovolemia
Kidney Int 2004; 65 (4):1499-1510

A. Santoro, E. Mancini
The kidney in hepatorenal syndrome
Int J Artif Organs 2004;27 (1):95-103

A. Santoro, E. Mancini, S. Buttiglieri, A. Krause, M.Yakubivich, C. Tetta
Extracorporeal support of liver function (II Part)
 Int J Artif Organs 2004;27 (3): 176-185

L.B. De Sanctis, M. Mandreoli, C. Poggi, S. Pileri, S. Casanova, A. Santoro
Acute renal failure in a young woman with Fisher-Evans’ syndrome
J Nephrol 2004; 17 (5); 739-743

M. Mandreoli, C. Finelli, A. Lopez, S. Ascani, N. Vinelli, M. Baccarani, A. Santoro
Successful resumption of epoetin alfa after rituximab treatment in a patient with pure red cell aplasia
Am J Kidney Dis 2004; 44 (4): 757-761

S. Faenza, E. Mancini, F. Petrini, A. Santoro, A. Zanoni, G. Martinelli
Role of intensive therapy in liver transplant recipients: experience in blood purification and biosynthetic techniques
Transplant Proc 2004; 36:555-557

G. Conti, A. Amore, M. Chiesa, D. Mancuso, P. Cirina, G. Mengozzi, A. Santoro, R. Coppo
Procalcitonin as a marker of micro-inflammationin hemodialysis
J Nephrol 2005;18: 282-288

A. Santoro, E. Mancini, L. Bibiano, A. Specchio et al.
On-line Convective Therapies: results from a Hemofiltration trial
Contrib Nephrol  2005;   149:51-57

A. Santoro, P.A. Conz, V. De Cristoforo, I. Acquistapace et al.
Mid-Dilution: the perfect balance between convection and diffusion
Contrib Nephrol 2005; 149:107-114

A. Santoro, E. Mancini, R. Gaggi, S. Cavalcanti et al.
Electrophysiological response to dialysis: the role of dialysate potassium content and profiling
Contrib Nephrol 2005; 149:295-305

R. Padrini, C. Canova, P. Conz, E. Mancini, E. Rizzioli, A. Santoro
Convective and adsorptive removal of b2-microglobulin during predilutional and postdilutional hemofiltration
Kidney Int 2005;68:1-7

S. Faenza, E. Beranrdi, F. Cuppini, A. Gatta, A. Lauro, E. Mancini, F. Petrini, E. Pierucci, Sangiorgi G, A. Santoro et al.  
Intensive care complications in liver and multivisceral transplantation
Transplant Proc 2005; 37(6):2618-2621

S. Passalacqua, E. Staffolani, G. Busnach, D. Roccatello, S. Pasquali et al. The Italian Registry for therapeutic apheresis. A report from the apheresis study group of the Italian Society of NephrologyJ Clin Apher 2005; 20(2):101-106

Santoro A, Faenza S, Mancini E, Ferramosca E et al. Prometheus system:  a technological support in liver failure. Transplantation  Proc 2006;38(4):1078-1082.
Faenza S, Santoro A, Mancini E, Pareschi S, Siniscalchi A, Zanzabni C, Pinna AD. Acute Renal Failure Requiring Renal Replacement Therapy After Orthotopic Liver Transplantation. Transplant Proc. 2006; 38(4):1141-2.
Mancini E, Mambelli E, Irpinia M, Alloatti S et al. Prevention of dialysis hypotension episodes using a fuzzy logic control. Nephrol Dialysis Transplant  In press
Santoro A, Mancini E, Ferramosca E, Faenza S. Liver Support Systems. Contrib  Nephrol, in press
Mancini E, Santoro A The kidney in Hepatorenal syndromeContrib Nephrol, in press
Santoro A. Cardiovascular dialysis instability and convective therapies Hemodial Intern 2006;(10):S51-S55
Santoro A, Canova C, Freyrie A, Mancini E.Vascular access for hemodialysis J Nephrol 2006  May-Jun;19(3):259-64
Santoro A, Monari C Control Procedures of the dialysis water treatment unit Atti III Corso di Formazione Tecnico Sanitaria ANTE 2005
Muntner P, Ferramosca E, Bellasi A, Block GA, Raggi P Development of a cardiovascular calcification index using simple imaging tools in haemodialysis patientsNephrol Dial Transplant 2006;18:1-7
Ferramosca E, Di Felice A, Ratti C, Ligabue G, Ibrahim D, Modena MG, Romagnoli R, Bagni B, Albertazzi A, Raggi PScreening for silent ischemia with coronary artery calcium and nuclear stress testing in nondiabetic J Nephrol 2006; 19(4):473-80
Bellasi A, Ferramosca E, Muntner P, Ratti C, Wildman RP, Block GA, Raggi P Correlation of simple imaging tests and coronary artery calcium measured by computed tomography in hemodialysis patientsKidney Int 2006;70(9):1623-8
 

European Fellows programme

Specify if the Unit accepts fellows from European countries for:
Short (1-2 month) well focused training programs either clinically or laboratory oriented: No
Long (at least 1 year) research fellowships: Yes
Specify corresponding availability of grants: Yes
Specify if the Unit may provide help for accommodation: Yes

Prerequisites for Fellowship

Language: English, French, Spanish

Work/Research experience: Hemodialysis (cardiovascular aspects, monitoring systems, new technologies, dialysis in critically ill patients), Glomerulonephritis, Systemic Diseases, Transplantation

Other prerequisites Stay > 6 months