EUROPEAN TRAINING CENTRES

Mannheim - The Water Tower

 

Vth Medical Department, University Hospital Mannheim,
Mannheim Germany

 

HEAD OF THE UNIT Fokko J. van der Woude, M.D., Ph.D
CLINICAL STAFF Oberärzte:
Prof. Hammes, Dr. Birck, Dr. Bode, PD Dr. Braun, Dr. Schmitt, PD Dr. Schnülle

Stationen-Ambulanzen:
Dr. Urs Benck, Agirim Busauschina, Dr. Christiane Ehehalt, Dr. Renate Engelleiter,
A. Habicht, ÄiP Hohenadel, Stefan Krzossok, Hannes Köppel, Smaragdi Marinaki,
Joachim Selhorst, ÄiP Zeller, Dr. Sabine Zosel,

AiP:
Matthias Bechtler, Dr. Paul Brinkkötter, Uwe Göttmann, Alexander Lammert,
Dr. Anna-Isabell Wille, Swee Wenning,

 

CONTACT INFORMATION
   
E-MAIL 5Medizinischeklinik@med5.ma.uni-heidelberg.de
PHONE: +49-621-3832340
FAX: +49-621-3833804
FULL POSTAL ADDRESS Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

 

CLINICAL FACILITIES
   
NEPHROLOGY BEDS N° 74 (16 hemodialysis)
HEMODIALYSIS PATIENTS N° 55
PERITONEAL DIALYSIS PATIENTS N° 25
INTENSIVE CARE NEPHROLOGY BEDS N° 6
RENAL TRANSPLANTS /YEAR (2001) N° 26

 

RESEARCH INTERESTS

CLINICAL RESEARCH

RESEARCH PROGRAMS AND PROJECTS LIST
Application of heparin and modified glycosaminoglycans for improvement of long-term prognosis of transplanted kidneys.

The genetics of the diabetic nephropathy.

Mechanisms of progression of chronic kidney failure.

International Graduate School "Vascular Medicine".

Peer Reviewed Publications in International Journals (only English) 2000-2003

Publications list

1. Giovanni Gambaro and Fokko J. van der Woude: Glycosaminoglycans: Use in Treatment of Diabetic Nephropathy. J Am Soc Nephrol 11: 359-368 (2000)
2. R. Birck, S. Krzossok, T. Knoll, C. Braun, F.J. van der Woude, P. Rohmeiss: Preferential
COX-2 Inhibitor, Meloxicam, Compromises Renal Perfusion in Euvolemic and Hypovolemic Rats. Exp Nephrol 8: 172-180 (2000)
3. Alexander Müller, Peter Schnülle, Ruediger Waldherr, and Fokko J. van der Woude: Impact of the Banff `97 classification for histological diagnosis of rejection on clinical outcome and renal function parameters after kidney transplantation. Transplantation Vol. 69, No. 6: 1123-1127 (2000)
4. Fokko J. van der Woude: Cocaine use and kidney damage. Nephrol Dial Transplant 15: 299-301 (2000)
5. Claude Braun, Stephan Vetter, Tobias Conzelmann, Meike Schaub, Michael Kirchengast, Fokko J. van der Woude, Peter Rohmeiss: Improved Recovery following Posttransplant Acute Renal Failure in Rat Renal Isografts with an Oral Endothelin-A-Receptor Antagonist. Exp Nephrol 8: 282-290 (2000)
6. Claude Braun, Tobias Conzelmann, Stephan Vetter, Meike Schaub, Walter E. Back, Michael Kirchengast, Stefan G. Tullius, Peter Schnülle, Fokko J. van der Woude and Peter Rohmeiss: Treatment with a Combined Endothelin A/B-Receptor Antagonist Does Not Prevent Chronic Renal Allograft Rejection in Rats. J of Cardiovascular Pharmacology 36: 428-437 (2000)
7. Alvan R. Feinstein, Lothar A.J. Heinemann, Gary C. Curhan, Elizabeth Delzell, Paul J. DeSchepper, Johannes M. Fox, Helmut Graf, Friedrich C. Luft, Paul Michielsen, Michael J. Mihatsch, Samy Suissa, Fokko J. van der Woude and Stefan Willich: Relationship between nonphenacetin combined analgesic and nephropathy: A review. Kidney International 58: 2259-2264 (2000)
8. Stefan P. Berger, Mathias Hünger, Benito A. Yard, Peter Schnuelle and Fokko J. van der Woude: Dopamine induces the expression of heme oxygenase-1 by human endothelial cells in vitro. Kidney International 58: 2314-2319 (2000)
9. Nowack R., Schwalbe K, Flores-Suárez L.F., Yard B., van der Woude F.J.: Upregulation of CD 14 and CD 18 on monocytes In vitro by antineutroph autoantibodies. J Am Soc Nephrol. 11 (9): 1639-1646 (2000)
10. C. Braun, M. Schultz, M. Schaub, L. Fang, W.E. Back, D. Herr, V. Laux, P. Schnuelle, P. Rohmeiss and F.J. van der Woude: Effect of Treatment With Low-Molecular-Weight Heparin on Chronic Renal Allograft Rejection in Rats. Transplant Proc. 33: 363-365 (2001)
11. B.A. Yard, S. Kahlert, R. Engelleiter, S. Resch, R. Waldherr, A.J. Groffen, L.P.W.J. van den Heuvel, J. van der Born, J.H.M. Berden, S. Kröger, M. Hafner, F.J. van der Woude: Decreased Glomerular Expression of Agrin in Diabetic Nephropathy and Podocytes, Cultured in High Glucose Medium. Exp Nephrol 9: 214-222 (2001)
12. F.J. van der Woude, W.H. Schmitt, R. Birck, R. Nowack, U. Göbel, J.M. Drexler and O. Hotta: Immunosuppression in ANCA-associated Vasculitis. Transplant Proc. 33: 2225-2226 (2001)
13. Claude Braun, Melanie Schultz, Liu Fang, Meike Schaub, Walter E. Back, Dieter Herr, Volker Laux, Peter Rohmeiss, Peter Schnuelle and Fokko J. van der Woude: Treatment of Chronic Renal Allograft Rejection in Rats With A Low-Molecular-Weight Heparin (Reviparin). Transplantation 72: 209-215 (2001)
14. Rainer Nowack, Ilona Grab, Luis-Felipe Flores-Suarez, Peter Schnülle, Benito Yard and Fokko J. van der Woude: ANCA titres, even of IgG subclasses, and soluble CD14 fail to predict relapses in patients with ANCA-associated vasculitis. Nephrol Dial Transplant 16: 1631-1637 (2001)
15. Peter Schnülle, Stefan Berger, Jan de Boer, Guido Perslin and Fokko J. van der Woude: Effects of Catecholamine Application to Brain-Dead Donors on Graft Survival in Solid Organ Transplantation. Transplantation 72: 455-463 (2001)
16. Wilhelm H. Schmitt, Ernst C. Hagen and Fokko J. van der Woude: T-cell directed treatment: anti-thymocyte globulin. Buchbeitrag: Kallenberg/Cohen Tervaert (eds.): Disease-modifying Therapy in Vasculides (PIR)
17. Jan Rabe, Peter Schnülle, Steffen J. Diehl, Dietmar Lorenz, Fokko J. van der Woude and Max Georgi: Unclear radiographic pulmonary changes in a patient who recently underwent renal transplantation. Nephrol Dial Transplant 16: 1490-1492 (2001)
18. Margreet Jonker, Yvon van den Hout, Riet C. Noort, Minke F. J. Versteeg van der Voort Maarschalk, Frans H. J. Claas, Fokko J. van der Woude, Daan Hollander, Norberto Perico and Giuseppe Remuzzi: Immunomodulation by Intrathymic Injection of Donor Leukocytes in Rhesus Monkeys. Transplantation 72, 8: 1432-1436 (2001)
19. Grietje Ch. Beck, Ralph Oberacker, Silke Kapper, Detlef von Zabern, Jutta Schulte, Klaus van Ackern, Fokko J. van der Woude and Benito A. Yard: Modulation of Chemokine Production in Lung Microvascular Endothelial Cells by Dopamine is Mediated via an Oxidative Mechanism. Am J Respir Cell Mol Biol 25: 636-643 (2001)
20. Benito Yard, Yuxi Feng, Hanno Keller, Christa Mall and Fokko van der Woude: Influence of high glucose concentrations on the expression of glycosaminoglycans and N-deacetylase/N-sulphotransferase mRNA in cultured skin fibroblasts from diabetic patients with or without nephropythy. Nephrol Dial Transplant 17: 386-391 (2002)
21. Peter Schnuelle, Jaap Homan van der Heide, Adam Tegzess, Cornelis A. Verburgh, Leendert C. Paul, Fokko Johannes van der Woude and Johan W. de Fijter: Open Randomized Trial Comparing Early Withdrawal of either Cyclosporine or Mycophenolate Mofetil in Stable Renal Transplant Recipients Initially Treated with a Triple Drug Regime: J Am Soc Nephrol 13: 536-543 (2002)
22. Fokko J. van der Woude: Graft Immunogenicity Revisited: Relevance of Tissue-Specific Immunity, Brain Death and Donor Pretreatment. Nephron 91: 181-187, (2002)
23. Claude Braun, Thomas Kleemann, Ulrich Hilgenfeldt, Udo Riester, Peter Rohmeiss and Fokko J. van der Woude: Activity and functional significance of the renal kallikreinkinin-system in polycystic kidney disease of the rat. Kidney Int Vol. 61: 2149-2156 (2002)
24. Correspondence: Tacrolimus and ciclosporin microemulsion in renal transplantation. Lancet Vol. 360: 799-801 (2002)
25. Fokko J. van der Woude: Taking anti-neutrophil cytoplasmic antibody (ANCA) testing beyond the limits. Nephrol Dial Transplant 17: 1-3 (2002)
26. Ulrike Niemann-Masanek, Alexander Müller, Benito A. Yard, Rüdiger Waldherr and Fokko J. van der Woude: B7-1 (CD80) and B7-2 (CD 86) Expression in Human Tubular Epithelial Cells inb vivo and in vitro. Nephron 92: 542-556 (2002)
27. Benito A. Yard, Saul Yedgar, Martin Scheele, Diane van der Woude, Grietje Beck, Bärbel Heidrich, Miron Krimsky, Fokko J. van der Woude and Stefan Post: Modulation of IFN-?-Induced Immunogenicity by Phosphatidylethanolamine-Linked Hyaluronic Acid. Transplantation Vol 73: 984-992 (2002)
28. Silke Kapper, Grietje Beck, Saskia Riedel, Katharina Prem, Markus Haak, Fokko J. van der Woude and Benito A. Yard: Modulation of Chemokine Production and Expression of Adhesion Molecules in Renal Tubular Epithelial and Endothelial Cells by Catecholamines. Transplantation Vol. 74: 253-260 (2002)
29. Irfan Vardarli, Leslie J. Baier, Robert L. Hanson, Imren Akkoyun, Christine Fischer, Peter Rohmeiss, Ali Basci, Claus R. Bartram, Fokko J. van der Woude and Bart Janssen: Gene for susceptibility to diabetic nephropathy in type 2 diabetes maps to 18q22.3-23. Kidney Int Vol. 62: 2176-2183 (2002)
30. Michael Morcos, Ahmend A.R. Sayed, Angeliks Bierhaus, Benito Yard, Rüdiger Waldherr, Wolfgang Merz, Ingrid Kloeting, erwin Schleicher, Stefani Mentz, Randa F. Abd el Baki, Hans Tritschler, Michael Kasper, Vedat Schwenger, Andreas Hamann, Klaus A. Dugi, Anne-Marie Schmidt, David Stern, Reinhard Ziegler, Hans U. Haering, Martin Andrassy, Fokko van der Woude and Peter Nawroth: Activation of Tubular Epithelial Cells in Diabetic Nephropathy. Diabetes Vol 51: 3532-3544 (2002)
31. Stefan Ockert, Frank Willeke, Axel Richter, Jens Jonescheit, Peter Schnuelle, Fokko van der Woude, Stefan Post: Total parathyroidecomie without autotransplantation as a standard procedure in the treatment of secondary hyperparathyroidism. Langenbeck´s Arch Surg 387: 204-209 (2002)
32. Claude Braun, Thomas Kleemann, Rainer Birck, Ulrich Hilgenfeldt, Udo Riester, Carsten Tschöpe, Fokko J. van der Woude, Peter Rohmeiss: Increased activity of the renal kallikrein-kinin system in autosomal dominant polycystic kidney disease in rats, but not in humans. Internat Immunopharmacology 2: 1949-1956 (2002)
33. G. Ch. Beck, B.A. Yard, J. Schulte, R. Oberacker, K. van Ackern, F. J. van der Woude, M. Krimsky, M. Kaszink and S. Yedgar: Inhibition of LPS-induced chemokine production in human lung endothelial cells by lipid conjungates anchored to the membrane. British J of Pharmacol 135: 1665-1674 (2002)
34. B.A. Yard, A.-I. Wille, M. Haak and F.J. van der Woude: Human proteinase 3 can inhibits LPS-mediated TNF-alpha production through CD14 degradation: lack of influence of antineutrophil cytoplasmic antibodies. Clin Exp Immunol 128: 444-452 (2002)
35. F.J. van der Woude: Kidney transplantation and ANCA-associated vasculitis. Cleve Clin J of Med 69 Suppl 2: SII 143-145 (2002)
36. L.F. Flores-Suárez, R. Nowack, B.A. Yard, C.-E. Dempfle and F.J. van der Woude: Effects of Anti-Neutrophil Cytoplasm Autoantibodies on Tissue Factor Activity by HL-60 Cells In Vitro. Scan J of Immunol 57: 68-78 (2003)
37. Wilhelm H. Schmitt, MD and Fokko J van der Woude, MD, PhD: Organ transplantation in the vasculitides. Current Opinion in Rheumatol 15: 22-28 (2003)
38. Rainer Birck, Klaus Warnatz, Hannes M. Lorenz, Mira Choi, Marion Haubitz, Mathias Grünke, Hans H. Peter, Joachim R. Kalden, Ursula Göbel, Johannes M. Drexler, Osamu Hotta, Rainer Nowack and Fokko J. van der Woude: 15-Deoxyspergualin in Patients with Refractory ANCA-Associated Systemic Vasculitis: A Six-Month Open-Label Trial to Evaluate Safety and Efficacy. J Am Soc Nephrol 14: 440-447 (2003)
39. Grietje Ch. Beck, Benito A. Yard, Jutta Schulte, markus Haak, Klaus van Ackern, Fokko J. van der Woude and Marietta Kaszkin: Secreted phospholipases A2 induce the expression of chemokines in microvascular endothelium. Biochem and Biophys Res Comm 300: 731-737 (2003)
40. Flores-Suárez LF, Cabiedes J, Villa AR, van der Woude FJ, Alcocer-Varela J: Prevalence of antineutrophil cytoplasmatic autoantibodies in patients with tuberculosis. Rheumatology (Oxford) 42 (2): 223-229 (2003)
41. H. Köppel, M. Christ, B.A. Yard, P.C. Bär, F.J. van der Woude ans M. Wehling: Nongenomic Effects of Aldosterone on Human Renal Cells. J of Endocrinology & Metabolism 88 (3): 1297-1302 (2003)
42. Jaime Davidson, Alan Wilkinson, Jacques Dantal, Francesco Dotta, Hermann Haller, Domingo Hernández, Bertram L. Kasiske, Bryce Kiberd, Andrew Krentz, Christophe Legendre, Piero Marchetti, Mariana Markell, Fokko J. van der Woude and David C. Wheeler: New-onset Diabetes after Transplantation: 2003 International Consensus Guidelines. Transplantation 75 (10): SS3-SS24 (2003)
43. Irmgard Neumann, Rainer Birck, Mark Newman, Peter Schnülle, Wilhelm Kriz, Kyuichi Nemoto, Benito Yard, Rüdiger Waldherr and Fokko J. van der Woude: SCG/Kinjoh mice: A model of ANCA-associated crescentic glomerulonephritis with immune deposits: Kidney International 64: 140-148 (2003)

 

European Fellows programme

Specify if the Unit accepts fellows from European countries for:
Short (1-2 month) well focused training programs either clinically or laboratory oriented NO
Long (at least 1 year) research fellowships YES
Specify if the Unit may provide help for accommodation YES

Prerequisites for Fellowship
Language
German