TRAINING CENTRE FORM
Salamanca, Spain |
Salamanca Major Square
DEPARTMENT, Department of Physiology and Pharmacology, Faculty of Medicine, University of Salamanca |
NAME OF THE UNIT Renal Physiopathology Unit |
Department Building, Home of the Renal Physiopathology Unit
Library
| HEAD OF THE UNIT | Prof. Jose M. López-Novoa |
| CLINICAL STAFF | Unit of Hypertension, Hospital Universitario de Salamanca: Angel Sanchez-Rodriguez, Juan F. Macías Nuñez |
| RESEARCH AND LABORATORY | Fernando Perez-Barriocanal Nélida Eleno Miguel Arevalo Carlos Martinez-Salgado Francisco Lopez-Hernandez Francisco J. García-Criado Alicia Rodriguez-Barbero Ana I. Morales |
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| CONTACT
INFORMATION |
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| E-MAIL: | jmlnovoa@usal.es |
| PHONE: | +34-923-294472 |
| FAX: | +34-923-294669 |
| FULL POSTAL ADDRESS: | Edificio Departamental, Campus Miguel de Unamuno, Universidad de Salamanca, E-37007 Salamanca, Spain |
| WEBSITE OF THE UNIT: | http://www3.usal.es/~labfisrencar/index2_e.html |
RESEARCH INTERESTS
CLINICAL RESEARCH
RESEARCH PROGRAMMESS AND PROJECTS LIST |
Alterations of small GTPase Ras signaling in hypertensive patients |
| BASIC RESEARCH |
RESEARCH PROGRAMMESS AND PROJECTS LIST |
Role of endoglin and ALK-1 in renal fibrosis |
Activation of small GTPase Ras and its signaling pathways in renal fibrosis |
Mechanisms of cisplatin-induced renal toxicity. |
Effect of NO donors on tubular necrosis and inflammation after kidney transplant in rats |
Peer Reviewed Publications in International Journals (only English) 2000-2006
| 1. | Increased apoptosis susceptibility in mesangial cells from spontaneously hypertensive rats. Rodriguez-Lopez AM, Flores O, Martinez-Salgado C, Eleno N, Lopez-Novoa JM, Arevalo M. Microvascular Research. 2000,59:80-87. |
| 2. | Potential
use of isolated glomeruli and cultured mesangial cells as in vitro models
to assess nephrotoxicity. Invited Review Rodriguez-Barbero A, L'Azou B, Cambar J, Lopez-Novoa JM. Cellular Biolpgy and Toxicology 2000;16:145-153. |
| 3. | Endoglin
expression in human and rat mesangial cells and its upregulation byTGF-beta1.
Rodriguez-Barbero A, Obreo J, Eleno N, Rodriguez-Pena A, Duwel A, Jerkic M, Sanchez-Rodriguez A, Bernabeu C, Lopez-Novoa JM. Biochemical and Biophysical Research Communication 2001;282:142-7. |
| 4. | Up-regulation
of endoglin, a TGF-beta-binding protein, in rats with experimental renal
fibrosis induced by renal mass reduction. Rodriguez-Pena A, Prieto M, Duwel A, Rivas JV, Eleno N, Perez-Barriocanal F, Arevalo M, Smith JD, Vary CP, Bernabeu C, Lopez-Novoa JM. Nephrology Dialysis and Transplantation 2001;16 Suppl 1:34-39. |
| 5. | Renal
ischemia in the rat stimulates nitric oxide synthesis. Valdivielso M, Crespo C, Alonso JR, Martínez-Salgado C, Eleno N, Arévalo M, Pérez-Barriocanal F, López-Novoa JM. American Journal of Physiology 280: R771-R779, 2001 |
| 6. | Effect
of chronic and progressive aortic constriction on renal function and
structure in rats. Gallego B, Arevalo, Flores O, Lopez-Novoa JM, Perez-Barriocanal F. Canadian Journal of Physiology and Pharmacology 2001;79:601-607. |
| 7. | Renal
fibrosis in diabetic and aortic-constricted hypertensive rats. Gallego B, Arévalo M, Flores O, JM. López-Novoa, Pérez-Barriocanal F. American Journal of Physiology 280: R1823-R1829, 2001 |
| 8. | Vascular
gene transfer driven by endoglin and ICAM-2 endothelial-specific promoters.
Velasco B, Ramirez JR, Relloso M, Li C, Kumar S, Lopez-Bote JP, Perez-Barriocanal F, Lopez-Novoa JM, Cowan PJ, d'Apice AJ, Bernabeu C. Gene Therapy 2001;8:897-904 |
| 9. | Expression
of endoglin in human mesangial cells: modulation of extracellular matrix
synthesis. Diez-Marques L, Ortega-Velazquez R, Langa C, Rodriguez-Barbero A, Lopez-Novoa JM, Lamas S, Bernabeu C. Biochimica Biophysica Acta. 2002;1587:36-44. |
| 10. | Transforming
growth factor-b1 induces collagen synthesis and accumulation via p38
mitogen-activated protein kinase (MAPK) pathway in cultured L6E9 myoblasts. Rodríguez-Barbero A., Obreo J.,. Yuste L, Montero J.C., Rodríguez-Peña A., Pandiella A., Bernabéu C. and López-Novoa J.M. FEBS Letters 513, 282-288, 2002. |
| 11. | In vivo
Bradykinin B2-Receptor Activation Reduces Renal Fibrosis. J P. Schanstra, E Neau, P Drogoz, M A. Arevalo, J M Lopez Novoa, D. Calise, C Pecher, M Bader, J-P Girolami, J-L Bascands. Journal of Clinical Investigation, 2002; 110: 371 - 379. |
| 12. | Involvement
of reactive oxygen species on gentamicin-induced mesangial cell contraction
and proliferation. Martínez-Salgado C, N Eleno, P Tavares, A Rodríguez-Barbero, J García-Criado, J P Bolaños, J M. López-Novoa, Kidney International, 6:1682-1692, 2002 |
| 13. | Protective
Effect of trans-Resveratrol on Gentamicin-Induced Nephrotoxicity. Morales AI, Buitrago JM, Santiago JM, Fernandez-Tagarro M, Lopez-Novoa JM, Perez-Barriocanal F. Antioxidants and Redox Signaling. 2002 Dec;4(6):893-8. |
| 14. | Endoglin
upregulation during experimental renal interstitial fibrosis in mice.
Rodríguez-Peña A, N Eleno, A Düwell, M Arévalo, F Pérez-Barriocanal, O Flores, N Docherty, C Bernabeu, M Letarte, and J M. López-Novoa Hypertension 40:7123-720, 2002 |
| 15. | Induction
of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary
cultures of mesangial cells Yunta M, A Rodríguez-Barbero, M Arévalo, J M. López-Novoa, P A. Lazo. Kidney International 63:534-542, 2003. |
| 16. | CD105
prevents apoptosis in hypoxic endothelial cells. Li C, Issa R, Kumar P, Hampson IN, Lopez-Novoa JM, Bernabeu C, Kumar S. Journal of Cell Science. 2003 , 116:2677-85 |
| 17. | Expression
of the TGF-b co-receptor endoglin in epidermal keratinocytes, and its
dual role in multistage mouse skin carcinogenesis. Quintanilla M, Ramirez JR, Pérez-Gómez E, Romero D, Velasco B Letarte M, Lopez-Novoa JM, and Bernabéu C. Oncogene, 22,:5976-5986, 2003 |
| 18. | Relative roles of endothelin-1 and angiotensin II in experimental post-ischemic acute renal failure. |
| Jerkic M, Z Miloradovic, A Jovovic, N Mihailovic-Stanojevic, JV Rivas Elena, D Nastiz-Miri, G Grujic-Adanja3, A Rodríguez-Barbero, J Markovic-Lipkovski, Srejko B. Vojvodic, M Vicens, and J M López-Novoa. | |
| Nephrol Dial Transplant 2004;19:83-94. | |
| 19. | Endoglin regulates nitric oxide-dependent vasodilatation. |
| Jerkic M, J. V. Rivas-Elena, M. Prieto, R. Carrón, F. Sanz-Rodriguez, F. Perez-Barriocanal, A. Rodríguez-Barbero, C. Bernabeu, and J. M. López-Novoa. | |
FASEB J. 2004 Mar;18(3):609-611 |
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| 20. | Gentamicin Treatment Induces Simultaneous Mesangial Proliferation and Apoptosis in Rats. |
| Martínez-Salgado C, N. Eleno, A Morales, F. Pérez-Barriocanal, M Arévalo, J. M. López-Novoa. | |
Kidney Int 2004 Jun;65(6):2161-71 |
|
| 21. | Sequential changes in redox status and nitric oxide synthases expression in the liver after bile duct ligation. |
| Vazquez-Gil MJ, Mesonero MJ, Flores O, Criado M, Hidalgo F, Arevalo MA, Sanchez-Rodriguez A, Tuñon MJ, Lopez-Novoa JM, Esteller A. | |
Life Sci. 2004 Jun 25;75(6):717-32. |
|
| 22. | Endoglin expression regulates basal and TGF-beta1 induced extracellular matrix synthesis in cultured L6E9 myoblasts. |
| Obreo J, Diez-Marques L, Lamas S, Rodriguez-Peña A, Jerkic M, Duwell A, Eleno N, Bernabeu C, Pandiella A, Lopez-Novoa JM , Rodriguez-Barbero A. | |
Cellular Physiol Biochem 2004;14(4-6):301-10. |
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| 23. | Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats. |
| Rodriguez-Pena A, Garcia-Criado FJ, Eleno N, Arevalo M, Lopez-Novoa JM | |
American Journal Transplantation 4, 1605 – 1613, 2004 |
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| 24. | Role of vascular nitric oxide in experimental liver cirrhosis. |
| Atucha NM, Nadal FJ, Iyu D, Alcaraz A, Rodriguez-Barbero A, Ortiz MC, Lopez-Novoa JM, Garcia-Estan J. | |
Curr Vasc Pharmacol. 2005 Jan;3(1):81-5. |
|
| 25. | Effect of the Long-Term Treatment with Trandolapril on Endoglin Expression in Rats with Experimental Renal Fibrosis Induced by Renal Mass Reduction. |
| Prieto M, Rodriguez-Pena A, Arevalo M, Rivas JV, Duwel A, Eleno N, Sanchez RJ, Morales AI, Lopez-Novoa JM, Perez-Barriocanal F. | |
Kidney Blood Press Res. 2005;28(1):32-40. |
|
| 26. | Activation of small GTPase Ras and renal fibrosis. |
| Rodriguez-Peña AB, Santos E, Arevalo M, Lopez-Novoa JM. | |
J Nephrol. 2005 May-Jun;18(3):341-9. |
|
| 27. | Exogenous nitric oxide modulates the systemic inflammatory response and improves kidney function after risk-situation abdominal aortic surgery. |
| Lozano FS, Lopez-Novoa JM, Rodriguez JM, Barros MB, Garcia-Criado FJ, Nicolas JL, Parreño A, Revilla J, Gomez-Alonso A. | |
| J Vasc Surg. 2005 Jul;42(1):129-39. | |
| 28. | Gentamicin induces Jun-AP1 expression and JNK activation in renal glomeruli and cultured mesangial cells. |
| Martinez-Salgado C, Rodriguez-Barbero A, Eleno N, Lopez-Novoa JM. | |
| Life Sci. 2005 16;77(18):2285-98. | |
| 29. | Characterization of murine S-endoglin isoform and its effects on tumor development. |
| Perez-Gomez E, Eleno N, Lopez-Novoa JM, Ramirez JR, Velasco B, Letarte M, Bernabeu C, Quintanilla M. | |
| Oncogene. 2005 Jun 23;24(27):4450-61. | |
| 30. | Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration. |
| Lopez-Rivera E, Lizarbe TR, Martinez-Moreno M, Lopez-Novoa JM, Rodriguez-Barbero A, Rodrigo J, Fernandez AP, Alvarez-Barrientos A, Lamas S, Zaragoza C. | |
| Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3685-90. | |
| 31. | Role of vascular nitric oxide in experimental liver cirrhosis. |
| Atucha NM, Nadal FJ, Iyu D, Alcaraz A, Rodriguez-Barbero A, Ortiz MC, Lopez-Novoa JM, Garcia-Estan J. | |
| Curr Vasc Pharmacol. 2005 Jan;3(1):81-5. Review. | |
| 32. | Glomerular actions of nephrotoxic substances. |
| Martinez-Salgado C, Rodriguez-Barbero A, Lopez-Novoa JM. | |
| Current Topics in Toxicology 1: 95-103, 2004 | |
| 33. | Temporal changes in renal endoglin and TGF-β1 expression following ureteral obstruction in rats. |
| Prieto, M, Rodriguez-Peña AB, Düwell A, Rivas JV, Docherty N, Pérez-Barriocanal F, Arévalo M, Vary CPH, Bernabeu C, López-Novoa JM, Eleno N. | |
| J. Physiol. Biochem. 61 (3) 457-467, 2005. | |
| 34. | Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. |
| Morales AI, Vicente-Sanchez C, Jerkic M, Santiago JM, Sanchez-Gonzalez PD, Perez-Barriocanal F, Lopez-Novoa JM. | |
Toxicol Appl Pharmacol. 2006 Jan;210(1-2):128-35. |
|
| 35. | Reduced angiogenic responses in adult endoglin heterozygous mice. |
| Jerkic M, Rodriguez-Barbero A, Prieto M, Toporsian M, Pericacho M, Rivas-Elena JV, Obreo J, Wang A, Perez-Barriocanal F, Arevalo M, Bernabeu C, Letarte M, Lopez-Novoa JM. | |
| Cardiovasc Res. 2006 69:845-54 | |
| 36. | The lord of the ring: Mandatory role of the kidney in drug therapy of hypertension. |
| Lopez-Hernandez, FJ, Lopez- Novoa, JM. | |
| Pharmacology & Therapeutics 2006 Jul;111(1):53-80. | |
| 37. | Resveratrol inhibits gentamicin-induced mesangial cell contraction. |
| Morales A, A. Rodríguez -Barbero, C. Vicente-Sánchez, J.M. López-Novoa, F. Pérez-Barriocanal | |
Life Sci. 2006; 78(20):2373-7. |
|
| 38. | Endoglin regulates renal ischemia-reperfusion injury. Nephrol. Dial. |
| Docherty N G., J M. Lopez-Novoa, M Arevalo, A Düwel, A. Rodriguez-Peña, F. Pérez-Barriocanal, C. Bernabeu, N. Eleno. | |
Nephrol. Dial. Transplant. 2006 Aug;21(8):2106-19 |
|
| 39. | Involvement of H- and N-Ras isoforms in transforming growth factor-β1-induced proliferation and in collagen and fibronectin synthesis. |
| Martínez-Salgado C, I Fuentes-Calvo, B García-Cenador, E Santos, J M. López-Novoa. | |
Exp Cell Res. 2006 Jul 1;312(11):2093-106. |
|
| 40. | Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction. |
| Sauzeau V, Sevilla MA, Rivas-Elena JV, de Alava E, Montero MJ, Lopez-Novoa JM, Bustelo XR. | |
Nature Medicine 2006 Jul;12(7):841-845 |
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| 41. | Mice deficient in telomerase activity develop hypertension due to an excess of endothelin production. |
| Perez-Rivero G, Ruiz-Torres MP, Rivas-Elena JV, Jerkic M, Diez-Marques ML, Lopez-Novoa JM, Blasco MA, Rodriguez-Puyol D. | |
| Circulation. 2006 Jul 25;114(4):309-17. | |
| 42. | Endoglin Regulates Cyclooxygenase-2 Expression and Activity. |
| Jerkic M, Rivas-Elena JV, Santibanez JF, Prieto M, Rodriguez-Barbero A, Pericacho M, Arevalo M, Vary CP, Letarte M, Bernabeu C, Lopez-Novoa JM. | |
Circ Res. 2006 99:248-256. |
|
| 43. | TGF-beta1 Induces Cox-2 Expression And Prostaglandin-E2 Synthesis Through Mapk And Pi3k Pathways In Human Mesangial Cells. |
| Rodriguez-Barbero A, Dorado F, Velasco S, Pandiella A, Banas B, Lopez-Novoa JM. | |
| Kidney Int Sep;70(5):901-909. | |
| 44. | Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. |
| Morales AI, Vicente-Sanchez C, Sandoval JM, Egido J, Mayoral P, Arevalo MA, Fernandez-Tagarro M, Lopez-Novoa JM, Perez-Barriocanal F. | |
| Food Chem Toxicol. 2006 Dec;44(12):2092-100 | |
| 45. | Endoglin modulation of TGF-beta1-induced collagen synthesis is dependent on erk1/2 MAPk activation |
| Santibanez JF, Letamendia A, Perez-Barriocanal F, Silvestri C, Saura M, Vary CP, Lopez-Novoa JM, Attisano L, Bernabeu C. | |
| J Cell Physiol. 2006 Oct 20;210(2):456-468 | |
| 46. | Reduced Tumor Growth and Angiogenesis in Endoglin-Haploinsufficient Mice. |
| Duwel A, Eleno N, Jerkic M, Arevalo M, Bolanos JP, Bernabeu C, Lopez-Novoa JM. | |
| Tumour Biol. 2006;28(1):1-8 |
European Fellows programme
Specify
if the Unit accepts fellows from European countries for:
Short (1-2 month) well focused training programs either clinically or
laboratory oriented: No
Long (at least 1 year) research fellowships: Yes
Specify corresponding availability of grants: No
Specify if the Unit may provide help for accommodation: Yes
Prerequisites for Fellowship
Language: (specify) English or Spanish.
Work/Research experience:(specify) Basic skills in animal handling or basic experience in cell biology.