European Training Centres

Franz Volhard Clinic, Helios-Klinikum, Berlin,

Medical Faculty of the Charité, Medical Faculty of the Charité,

Department of Nephrology/Hypertension

Berlin, Germany

HEAD OF THE UNIT	Prof. Friedrich Luft
CLINICAL STAFF	Friedrich C. Luft, Ralph Kettritz, Ursula Göbel
RESEARCH AND LABORATORY	Ralph Kettritz, Jens Jordan, Dominik N. Müller, Sylvia Bähring

NAME OF THE UNIT	Nephrology/Hypertension; Franz Volhard Clinic
E-MAIL	Luft@charite.de or Kettritz@charite.de
TEL	+49-30-9417-2202
FAX	+49-30-9417-2206
FULL POSTAL ADDRESS	Wiltbergstrasse 50, 13125 Berlin, Germany
WEBSITE OF THE UNIT	http://www.rrk-berlin.de/

CLINICAL FACILITIES
NEPHROLOGY BEDS N°	54
HEMODIALYSIS PATIENTS N°	35
PERITONEAL DIALYSIS PATIENTS N°	15
INTENSIVE CARE NEPHROLOGY BEDS N°	We cover 5 ICUs. FCL is certified and director of education in our ICUSs.

RESEARCH INTERESTS

We have a comprehensive program in molecular genetics of cardiovascular disease, ANCA vasculitis, Patient-oriented research in hypertension and metabolism including a CRC, target-organ damage, patch clamp, and cell signal transduction (see publications below):

Peer Reviewed Publications in International Journals (only English) 2003-2006

Publications List

2003

413. Boschmann M, Jordan J, Adams F, Tank J, Franke G, Stoffels M, Luft FC, Klaus S. Angiotensin II and nitric oxide interaction effects on perfusion and metabolism in adipose tissue and muscle. Hypertension 2003;41 37-41.

414. Schreiber A, Busjahn A, Luft FC, Kettritz R. The expression of proteinase 3 is genetically determined. J Am Soc Nephrol 2003;14:68-75.

415. Obst M, Gross V, Janke J, Schneider W, Luft FC. Pressure natriuresis in AT2-receptor deficient mice with L-NAME hypertension. J Am Soc Nephrol 2003;14:303-10.

416. Choi M, Rolle S, Rane M, Haller H, Luft FC, Kettritz R. Extracellular signal-regulated kinase inhibition by statins inhibits neutrophil activation by anti-neutrophil cytoplasmic antibodies. Kidney Int 2003;63:96-106.

417. Loggen U, Boden A, Schuster H, Tolle R, Netwich U, Dupon C, Muller-Myhsok B, Baron H, Luft FC. Apolipoprotein B-100 gene mutations and cholesterol control in German patients. Atherosclerosis. 2003 ;166:411-2.

418. Dechend R, Müller DN, Viedt C, Wallukat G, Park J-K, Theuer J, Barta P, Homuth V, Fiebeler A, Kreuzer J, Dietz R, Haller H, Luft FC. AT1 receptor antibodies from preeclamptic patients stimulate NADPH oxidase. Circulation 2003;107:1632-9.

419. Mervaala E, Finckenberg P, Lapatto R, Dechend R, Park JK, Muller DN, Ganten D, Vapaatalo H, Luft FC. Lipoic acid supplementation prevents angiotensin II-induced end-organ damage. Kidney Int 2003 ; 64:501-508.

420. Engeli S, Feldpausch M, Gorzelniak K, Hartwig F, Heintze U, Janke J, Luft FC, Sharma AM. Adiponectin gene expression, insulin sensitivity, and inflammatory markers in obese women. Diabetes 2003;52:942-947.

421. Gross V, Luft FC. Exercising restraint in measuring blood pressure in conscious mice. Hypertension 2003;41 879-881.

422. Gong M, Zhang H, Schulz H, Lee YA, Sun K, Bahring S, Luft FC, Nurnberg P, Reis A, Rohde K, Ganten D, Hui R, Hubner N. Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p. Hum Mol Genet. 2003;12:1273-1277.

423. Wallukat G, Neichel D, Nissen E, Homuth V, Luft FC. Agonistic autoantibodies directed against the angiotensin II AT1 receptor in patients with preeclampsia. Can J Physiol Pharmacol. 2003;81:79-83.

424. Dechend R, Gieffers J, Dietz R, Joerres A, Luft FC, Maass M. HMG-CoA reductase inhibition reduces Chlamydia pneumoniae-induced macrophage vascular smooth muscle cell interaction and activation. Circulation 2003; 108: 261-5.

425. Elger M, Hentschel H, Litteral J, Wellner M, Kirsch T, Luft FC, Haller H. Nephrogenesis is induced by partial nephrectomy in the elasmobranch Leucoraja erinacea. J Am Soc Nephrol 2003; 14: 1506-1518.

426. Embark HM, Böhmer C, Vallon V, Luft FC, Lang F. Regulation of KCNE1 dependent K+ current by the serum glucocorticoid dependent kinase (SGK) isoforms. Pflügers Archiv 2003; 445: 691-6.

427. Jedrusik P, Januszewicz A, Busjahn A, Zawadzki B, Wocial B, Ignatowska-Switalska H, Berent H, Kuczynska K, Oniszczenko W, Strelau J, Luft FC, Januszewicz W. Genetic influence on blood pressure and lipid parameters in a sample of Polish twins. Blood Press. 2003;12:7-11.

428. Lipp A, Tank J, Stoffels M, Arnold G, Luft FC, Jordan J. Riluzole and blood pressure in multiple system atrophy. Clin Auton Res. 2003;13:271-4.

429. Bezzina CR, Verkerk AO, Busjahn A, Jeron A, Erdmann J, Hense H-W, Koopmann TT, Bhuiyan ZA, Wilders R, Mannens MMAM, Tan HL, Luft FC, Schunkert H, Wilde AA. A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization. Cardiovasc Res 2003;59:27-36.

430. Radermacher J, Mengel M, Ellis S, Stuht S, Hiss M, Eisenberger U, Burg M, Luft FC, Gwinner W, Haller H. Early resistance index predicts long-term renal allograft survival. N Engl J Med 2003;349:115-24.

431. Luft FC, Toka O, Toka H, Jordan J, Bähring S. Mendelian hypertension with brachydactyly as a molecular genetic lesson in regulatory physiology. Am J Phys 2003;285:R709-14.

432. Tank J, Schroeder C, Stoffels M, Diedrich A, Sharma AM, Luft FC, Jordan J. Pressor effects of water drinking in tetraplegic patients involves a spinal reflex. Hypertension 2003;41:1234-9.

433. Tank J, Schröder C, Diedrich A, Szczech CE, Haertter S, Sharma AM, Luft FC, Jordan J. Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition. Circulation 2003; 107:2949-54.

434. Wellner M, Herse F, Janke J, Gorzelniak K, Engeli S, Bechart D, Lasalle P, Luft FC, Sharma AM. Endothelial cell-specific molecule-1, a newly indentified protein in adipocytes. Horm Metab Res 2003; 35: 217-221.

435. Al-Kateb H, Bautz E, Luft FC, Bähring S. A splice mutation in a Syrian autosomal-recessive familial hypercholesterolemia family causes a two nucleotide deletion of mRNA. Circ Res 2003;93:E49-50.

436. Finckenberg P, Inkinen K, Ahonen J, Merasto S, Vapaatalo H, Müller DN, Ganten D, Luft FC, Mervaala E. Angiotensin II induces connective tissue growth factor expression via calcineurin-dependent pathways. Am J Pathol 2003; 107:355-66.

437. Lindschau C, Quass P, Maasch C, Alexander G, Kang N, Luft FC, Haller H. Glucose-induced expression of TGF-b1 and TGF-b receptor 1 in vascular smooth muscle cells is mediated by protein kinase C-alpha. Hypertension 2003;42:335-341.

438. Choi M, Rolle S, Wellner M, Scheidereit C, Cardoso MC, Luft FC, Kettritz R. Inhibition of NF-kB by a TAT-NEMO-binding domain peptide accelerates constitutive apoptosis and abrogates LPS-delayed neutrophil apoptosis. Blood 2003;102:2259-67.

439. Tank J, Jordan J, Diedrich A, Schroeder C, Stoffels M, Franke G, Sharma AM, Luft FC, and Brabant G. Leptin and sympathetic outflow in non-obese men. J Clin Endocrinol Metabol 2003;88:4955-4959.

440. Diedrich A, Jordan J, Tank J, Shannon JR, Robertson R, Luft FC, Robertson D, Biaggioni I. The sympathetic nervous system in essential hypertension. J Hypertens 2003;21:1677-1686.

441. Titze J, Lang R, Ilies C, Schwind KH, Kirsch KA, Dietsch P, Luft FC, Hilgers KF. Osmotically inative skin sodium storage in rats. Am J Physiol 2003;285:F1108-17.

442. Helkamaa T, Rauhala P, Reenilä I, Zhong J-C, Finkenberg P, Männistö P, Müller DN, Luft FC, Mervaala EMA. Entacapone protects from angiotensin II-induced inflammation and renal injury. J Hypertens 2003;21:2353-2363.

443. Boschmann M, Steiniger J, Hille U, Tank J, Shannon JR, Sharma AM, Klaus S, Robertson D, Luft FC, Jordan J. Water-induced thermogenesis. J Clin Endocrinol Metabol 2003 88: 6015-6019.

2004

444. Aydin A, Luft FC, Bähring S. Fluorescence-labeled nonhuman sequences facilitate SSCP. Anal Biochem 2004;324:16-21.

445. Fiebeler A, Park J-K, Müller DN, Lindschau C, Mengel M, Dechend R, Luft FC, Haller H. Gas6/Axl signaling in human inflammatory renal disease. Am J Kidney Dis 2004;43:286-295.

446. Bähring S, Rauch A, Toka O, Schroeder C, Hesse C, Siedler H, Fesüs G, Haefeli W, Busjahn A, Aydin A, Neuenfeld Y, Mühl A, Toka H, Gollasch M, Jordan J, Luft FC. Autosomal-dominant hypertension with type E brachydactyly is caused by a rearrangement on the short arm of chromosome 12. Hypertension 2004;43:471-6.

447. Kettritz R, Choi M, Rolle S, Luft FC. Synergistic effects of integrins and cytokines in NF-kB activation in human neutrophils. J Biol Chem 2004; 279: 2657-2665..

448. Engeli S, Feldpausch M, Gorzelniak K, Heintze U, Janke J, Luft FC, Sharma AM. Regulation of 11 ß-hydroxysteroid dehydrogenase in human adipose tissue. Obes Res 2004;12: 9-17.

449. Brinsuk M, Tank J, Luft FC, Busjahn A, Jordan J. Heritability of venous function in humans. Arterioscler Thromb Vasc Biol 2004;24:207-11.

450. Titze J, Rittweger J, Dietsch P, Krause H, Schwind KH, Engelke K, Lang R, Kirsch KA, Luft FC, Hilgers KF. Hypertension, sodium retention, calcium excretion, and osteopenia in Dahl rats. J Hypertens 2004;22:803-810.

451. Mazak I, Fiebeler A, Müller DN, Park J-K, Shagdarsuren E, Lindschau C, Dechend R, Pilz B, Haller H, Luft FC. Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells. Circulation 2004;109:2792-2800.

452. Schreiber A, Luft FC, Kettritz R. Role of membrane proteinase 3 expression in ANCA-induced neutrophil activation. Kidney Int 2004;65:2172-83..

453. Gross V, Obst M, Kiss E, Janke J, Groene H-J, Luft FC. Cardiac hypertrophy and fibrosis in chronic L-NAME treated AT2 receptor-deficient mice. J Hypertens 2004;22:997-1005.

454. Dragun D, Böhler T, Nieminen-Kelhä M, Waiser J, Schneider W, Haller H, Luft FC, Neumayer H-H, Budde K. FTY720 induced lymphocyte homing modulates post-transplant preservation/reperfusion injury. Kidney Int 2004;65:1076-83.

455. Dubrovska G, Verlohren S, Luft FC, Gollasch M. Mechanisms of ADRF release from rat aortic adventitial adipose tissue. Am J Physiol 2004;286:H1107-13.

456. Obst M, Bonartsev A, Gross V, Jahnke J, Müller DN, Park J-K, Kärgel E, Luft FC. Nitric oxide synthase expression in AT2-receptor deficient mice after DOCA-salt. Kidney Int 2004;65:2268-78.

457. Müller DN, Theuer J, Shagdarsuren E, Kaergel E, Honeck H, Park J-K, Markovic M, Barbosa-Sicard E, Dechend R, Wellner M, Kirsch T, Fiebeler A, Haller H, Luft FC, Schunck W-H. A PPAR-alpha activator restores renal CYP2C23 activity and protects from Ang II-induced renal injury. Am J Pathol 2004;164:521-32.

458. Jefferies CA, Hofman PL, Knoblauch H, Luft FC, Robinson EM, Cutfield WS. Twin children are insulin resistant with further resistance in twins with peroxisome proliferative activated receptor gamma polymorphism. J Pediatrics 2004;144:608-13.

459. Schroeder C, Adams A, Boschmann M, Tank J, Härtter S, Diedrich A, Biaggioni I, Luft FC, Jordan J. Gender differences in cardiovascular effects of norepinephrine transporter inhibition. Am J Physiol 2004;286:R851-856.

460. Jordan J, Furlan R, Tank J, Luft FC, Boschmann M. Adrenergic regulation of adipose tissue lipolysis in autonomic failure. Clin Autonom Res 2004;14:80-83.

462. Knoblauch H, Bauerfeind A, Toliat M, Becker C, Luganskaja T, Günther U, Rohde K, Schuster H, Junghans C, Luft FC, Nürnberg P, Reich JG. Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density and low-density lipoprotein cholesterol. Hum Mol Genet 2004;13:993-1004.

463. Tank J, Diedrich A, Szczech E, Luft FC, Jordan J. Alpha-2 adrenergic transmission and human baroreflex regulation. Hypertension 2004;43:1035-41.

464. Tank J, Jordan J, Diedrich A, Plehm R, Luft FC, Gross V. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension 2004;43:1042-7.

465. Busjahn A, Aydin A, Luft FC, Lang F. Association of the serum and glucocorticoid-regulated kinase (SGK1) gene with QT interval. Cell Physiol Biochem 2004; 14:135-142.

466. Verlohren S, Dubrovska G, Tsang S-Y, Essin K, Luft FC, Huang Y, Gollasch M. Visceral periadventitial adipose tissue regulates arterial tone of small mesenteric arteries. Hypertension 2004;44:271-276.

467. Obst M, Gross V, Luft FC. Systemic hemodynamics in conscious L-NAME and DOCA-salt-treated mice. J Hypertens 2004;22:1889-94.

468. Dieter M, Busjahn A, Palmada M, Boehmer C, Luft FC, Lang F. Regulation of sodium-coupled glucose transporter SGLT-1 by ubiquitin ligase NEDD4-2 and the serum and glucocorticoid-dependent kinase SGK1. Obes Res 2004;12:862-70.

469. Engeli S, Janke J, Gorzelniak K, Bohnke J, Ghose N, Lindschau C. Luft FC, Sharma AM. Regulation of the nitric oxide system in human adipose tissue. J Lipid Res 2004;45:1640-8.

470. Schroeder C, Tank J, Goldstein DS, Stoeter M, Haertter S, Luft FC, Jordan J. Influence of St. John’s Wort on catecholamine turnover and cardiovascular regulation in humans. Clin Pharmacol Ther 2004;76:480-9.

471. Tinschert S, Ruf N, Bernascone I, Sacherer K, Lamorte G, Neumayer HH, Nürnberg P, Luft FC, Rampoldi L. Functional consequences of a novel uromodulin mutation in a familial juvenile hyperuricemic nephropathy family. Nephrol Dial Transplant 2004;19:3150-4.

2005

472. Bachmann S, Mutig K, Bates J, Welker P, Gross V, Luft FC, Alenina N, Bader M, Thiele BJ, Prasadan K, Raffi HS, Kumar S. Renal effects of Tamm Horsfall protein (uromodulin) deficiency in mice. Am J Physiol 2005;288:F559-67.

473. Theuer J, Shagdarsuren E, Müller DN, Kaergel E, Honeck H, Park J-K, Fiebeler A, Dechend R, Haller H, Luft FC, Schunck W-H. Indicible nitric oxide synthase inhibition, eicosapentaenoic acid supplementation, and angiotensin II-induced renal damage. Kidney Int 2005;67:248-58.

474. Gross V, Tank J, Plehm R, Obst M, Blumer KJ, Diedrich A, Jordan J, Luft FC. Autonomic nervous system and blood pressure regulation in RGS2-defient mice. Am J Physiol 2005;288:R1134-42.

475. Dechend R, Gratze P, Shagdarsuren E, Wallukat G, Bräsen J-H, Schneider W, Plehm R, Luyten C, Pijnenborg R, Luft FC, Müller DN. Agonistic antibodies to the AT1 receptor in a transgenic rat model of preclampsia. Hypertension 2005;45:742-6.

476. Utz W, Jordan J, Niendorf T, Luft FC, Dietz R, Friedrich MG. Endothelial-dependent forearm tissue oxygenation with magnetic resonance imaging. Arterioscler Thromb Vasc Biol 2005;25:1408-13.

477. Bräsen JH, Nieminen-Kelhä M, Markmann D, Malle E, Schneider W, Neumayer HH, Budde K, Luft FC, Dragun D. Lectin-like oxidized LDL receptor (LOX-1) mediated pathway and vascular oxidative injury in older-age rat renal transplants. Kidney Int 2005;67:1583-94.

478. Aydin A, Bähring S, Dahm S, Guenther UP, Uhlmann R, Busjahn A, Luft FC. Single nucleotide polymorphism map of five long QT genes. J Mol Med 2005;83:159-65.

479. Adams F, Jordan J, Klaus S, Luft FC, Boschmann M. Blood flow in subcutaneous adipose tissue is dependent on skin fold thickness. Hormone Metab Res 2005;37:68-73..

480. Dragun D, Müller DN, Bräsen J-H, Fritsche L, Nieminen M, Dechend R, Kintscher U, Rudolph B, Hoebeke J, Eckert D, Mazak I, Plehm R, Schönemann C, Unger T, Budde K, Neumayer H-H, Luft FC, Wallukat G. Angiotensin II type 1 receptor-activating antihodies in renal allograft rejection. N Engl J Med 2005;352:558-69.

481. Finckenberg P, Merasto S, Lindren L, Vapaatalo H, Müller DN, Luft FC, Mervaala EMA. Magnesium supplementation prevents angiotensin II-induced myocardial damage and CTGF overexpression. J Hypertens 2005;23:375-380.

482. Wellner M, Park J-K, Shagdarsuren E, Dechend R, Al-Saach N, Kirsch T, Fiebeler A, Haller H, Luft FC, Müller DN. Altered gene expression in rats with terminal heart failure and cachexia. Physiol Genomics 2005;20:256-67.

483. Titze J, Bauer K, Schafflhuber M, Dietsch P, Lang R, Schind K-H, Luft FC, Eckardt K-U, Hilgers KF. Internal sodium balance in desoxycorticosterone acetate-salt rats: a body composition study. Am J Physiol 2005;289:F793-F802.

484. Engeli S, Böhnke J, Gorzelniak K, Janke J, Schling P, Bader M, Luft FC, Sharma AM. Weight loss and the renin-angiotensin-aldosterone system. Hypertension 2005;45:356-62.

485. Fiebeler A, Nussberger J, Shagdarsuren E, Rong S, Hilfenhaus G, Al-Saadi N, Dechend R, Wellner M, Meiners S, Maser-Gluth C, Jeng AY, Webb RL, Luft FC, Müller DN. An aldosterone synthase inhibitor ameliorates angiotensin II-induced end-organ damage. Circulation 2005;111:3087-94.

486. Jordan J, Brabant G, Brinsuk M, Tank J, Horn R, Luft FC, Busjahn A. Heritability of free and receptor-bouond leptin in normal twins. Am J Physiol 2005;288:R1411-6.

487. Salanova B, Choi M, Rolle S, Wellner M, Scheidereit C, Luft FC, Kettritz R. TNF-a signaling in neutrophils exposed to fever-like temperatures. FASEB J. 2005;19:816-8.

488. Birkenfeld, AL, Boschmann M, Moro C, Heusser K, Schroeder C, Berlin M, Luft FC, Lafontan M, Jordan J. Metabolic responses to atrial natriuretic peptide in humans J Clin Endocrinol Metabol 2005;90:3622-8.

489. Philipp S, Ollmann H, Schinck T, Dietz R, Luft FC, Willenbrock R. The impact of anemia and kidney function in congestive heart failure and preserved systolic function. Nephrol Dial Transplant 2005;20:915-9.

490. Schreiber A, Otto B, Ju X, Zenke M, Goebel U, Luft FC, Kettritz R. Membrane proteinase 3 expression in Wegener’s granulomatosis patients and in human hematopoeitic stem cell-derived neutrophils. J Am Soc Nephrol 2005;16:2216-24.

491. Yagil C, Hubner N, Monti J, Schultz H, Sapojnikov M, Luft FC, Ganten D, Yagil Y. Genomics and transcriptomics to find hypertension-related genes in Sabra rats. Circ Res 2005;96:617-625.

492. Tank J, Diedrich A, Szczech E, Luft FC, Jordan J. Baroreflex regulation of sympathetic vasomotor tone in men and women. Hypertension 2005;46:1159-1164.

493. Birkenfeld A, Schroeder C, Pischon T, Tank J, Luft FC, Sharma AM, Jordan J. Paradoxical effect of sibutramine on autonomic cardiovascular regulation in obese hypertensive subjects. Clin Autonom Res 2005;15:200-6.

494. Boschmann M, Engeli S, Adams F, Gorzelniak K, Franke G, Klaua S, Sharma AM, Luft FC, Jordan J. Relationship between adipose tissue metabolism and monocyte activation in obese hypertensive patients. Hypertension 2005;46:130-136.

495. Shushakova N, Eden G, Dangers M, Zwirner J, Menne J, Luft FC, Haller H, Dumler I. The urokinase/urokinase receptor system mediates the IgG immune complex-induced inflammation in the lung. J Immunol 2005;175:4060-8.

496. Pilz B, Shagdarsuren E, Wellner M, Fiebeler A, Dechend R, Feldman D, Webb RL, Luft FC, Müller DN. Aliskiren, a human renin inhibitor, reverses cardiac and renal damage in double-transgenic rats. Hypertension 2005;46:569-76.

497. Schroeder C, Vernino SA, Birkenfeld AL, Tank J, Heusser K, Lipp A, Benter T, Lindschau K, Kettritz R, Luft FC, Jordan J.Plasma exchange for primary autonomic failure. N Engl J Med 2005;353:1585-90.

498. Dietrich A, Gollasch M, Gross V, Dubrovska G, Storch U, Lauterbach B, Obst M, Essine K, Chubanov V, Meederos Y, Schnitzler M, Renz H, Luft FC, Gudermann T, Birnbaumer L. Genetic inactivation in mice reveals a non-redundant role of TRPC6 for the regulation of airway and vascular smooth muscle tone. Mol Cell Biol 2005;25:6980-9.

499. Lipp A, Tank J, Franke G, Arnold G, Luft FC, Jordan J. Osmosensitive mechanisms contribute to the water drinking-induced, sympathetically-mediated, pressor response. Neurology 2005;65:905-7.

500. Engeli S, Böhnke J, Feldpausch M, Gorzelniak K, Janke J, Batkai S, Pacher P, Luft FC, Sharma AM, Jordan J. The peripheral endocannabinoid system in human obesity. Diabetes 2005;54:2838-43.

501. Shagdarsuren E, Wellner M, Braesen J-H, Park J-K, Fiebeler A, Henke N, Dechend R, Luft FC, Müller DN. C-reactive protein and complement in angiotensin II-induced organ damage. Circ Res 2005;97:716-24.

502. Jordan J, Engeli S, Boschmann M, Weidinger G, Luft FC, Sharma AM, Kreutzberg U. Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients. J Hypertens 2005:23:2313-8.

2006

503. Boschmann M, Engeli S, Adams F, Franke G, Luft FC, Sharma AM, Jordan J. Influences of AT1 receptor blockade on interstitial metabolism in obese men. Am J Physiol 2006;290:R219-23.

504. Janke J, Engeli S, Gorzelniak K, Feldpausch M, Heintze U, Böhnke J, Wellner M, Herse F, Lassalle P, Luft FC, Sharma AM. Adipose-tissue and circulating endothelial cell-specific molecule-1 in human obesity. Hormone Metab Res 2006;38:28-33.

505. Kettritz R, Wilke S, Luft FC, Schneider W. Apoptosis, proliferation, and inflammatory infiltration in ANCA-positive glomerulonephritis. Clin Nephrol 2006; 65: 443-445.

506. Obst M, Tank J, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC, Gross V. NO-dependent blood pressure regulation in RGS-2 deficient mice. Am J Physiol 2006;290:R1012-9.

507. Heusser K, Tank J, Diedrich A, Engeli S, Klaua S, Krüger N, Stoffels G, Luft FC, Jordan J. Sibutramine treatment inhibits sympathetic vasomotor tone in obese subjects. 2005. Clin Pharmacol Ther 2006; 79:500-508.

508. Kettritz R, Choi M, Salanova B, Wellner M, Rolle S, Luft FC. Fever-like temperatures abrogate Toll-like receptor 4-mediated LPX apoptosis by dissociating heat shock protein 90 from the inibitor of kB kinase complex. J Am Soc Nephrol 2006; 17: 1345-1353.

509. Mayer AF, Schroeder C, Heusser K, Tank J, Diedrich A, Schmieder RE, Luft FC, Jordan J. Influences of norepinephrine transporter function on the distribtuion of sympathetic activity in humans. Hypertension 2006;48:120-6.

510. Galvez B, de Castro J, Herold D, Dubrovska G, Aranguez I, Luft FC, Gollasch M, Ramos MP, Fernandez-Alfonso MS. Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol 2006; 26: 1297-1392.

511. Schroeder C, Birkenfeld AL, Mayer AF, Tank J, Diedrich A, Luft FC, Jordan J. Norepinephrine transporter inhibition prevents tilt-induced syncope. J Am Coll Cardiol 2006;48:516-22.

512. Bauerfeind A, Knoblauch H, Constanza MC, Luganskaya T, Reza Toliat M, Nürnberg P, Luft FC, Reich J-G and Morabia A. Common single nucleotide polymorphisms, low-density, and high-density lipoprotein cholesterol in two independent popualtions: a comparative analysis. Hum Hered 2006; 61: 123-131.

513. Titze J, Luft FC, Bauer K, Dietsch P, Lang R, Schwind KH, Eckardt K-U, Hilgers KF. Salt-sensitivty and volume sensitivity in fertile and ovariectomized desoxycorticosterone acetate-salt rats. Hypertension 2006; 47: 1101-7.

514. Knauf F, Teichert C, Mohebbi N, Herold D, Rogina B, Helfand S, Gollasch M, Luft FC, Aronson PS. Identification of the transport mechanism mediated by the life-extending Indy gene. Biochemistry J 2006; 397: 25-9.

515. Janke J, Schupp M, Engeli S, Gorzelniak K, Sauma L, Nystrom FH, Luft FC, Sharma AM. PPARg activation by angiotensin type 1 receptor antagonists induces human in vitro adipogenesis. J Hypertens 2006;24:1809-16.

516. Boschmann M, Adams F, Klaus S, Sharma AM, Luft FC, Jordan J. Differential effect of interstitial angiotensin II in normal weight and obese men. J Hypertens 2006;24:1165-71.

517. Janke J, Engeli S, Böhnke J, Boschmann M, Adams F, Luft FC, Sharma AM, Jordan J. Retinol binding protein 4 in human obesity. Diabetes 2006;55:2805-10.

518. von Vietinghoff S, Busjahn A, Schönemann C, Arnold R, Otto B, Luft FC, Kettritz R. The major histocompatibility complex HLA locus largely explains the genetic variance exercised on neutrophil membrane proteinase 3 expression. J Am Soc Nephrol 2006;17:3185-91.

519. Engeli S, Boschmann M, Janke J, luft FC, Heer M, Jordan J. Influence of salt intake on renin-angiotensin and natriuretic peptide system genes in human adipose tissue. Hypertension 2006;48:1103-8.

520. Adams F, Boschmann M, Heer M, Schaller K, Franke G, Gorzelniak K, Janke J, Luft FC, Klaus S, Jordan J. Tyramine in the assessment of regional adrenergic function. Biochem Pharmacol 2006;72:1724-9.

521. Birkenfeld AL, Boschmann M, Moro C, Adams F, Heusser C, Franke G, Berlan M, Luft FC, Lafontan M, Jordan J. Interaction of atiral natriuretic peptide and beta adrenergic stimulation on human metabolism. J Clin Endocrinol Metab 2006;91:5069-75.

522. Boschmann M, Kreuzberg U, Engeli S, Adams F, Franke G, Klaua S, Scholze J, Luft FC, Sharma AM, Jordan J. The effect of oral glucose loads on skeletal muscle and fat metabolism during angiotensin II receptor and beta blockade in obese hypertensive subjects. Hormone Metab Res 2006;38:323-9.

2007

523. Muller DN, Schmidt C, Barbosa-Sicard E, Wellner M, Gross V, Hercule H, Markovic M, Honeck H, Luft FC, Schunck W-H. Mouse Cyp4a isoforms: enzymatic properties, sex and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Biochem J 2007 [pubmed].

524. Park J-K, Fischer R, Dechend R, Shagdarsuren E, Gapeljuk A, Wellner M, Meiners S, Gratze P, Al-Saadi N, Feldt S, Fiebeler A, Madwed JB, Schirdewan A, Haller H, Luft FC, Muller DN. P38 mitogen-activated protein kinase a/b inhibition ameliorates angiotensin II-induced target organ damage. Hypertension 2007 (in press).

525. Herse F, Dechend R, Harsem NK, Wallukat G, Janke J, Qadri F, Hering L, Muller DN, Luft FC, Staff AC. Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia. Hypertension 2007 (in press).

526. Hubel CA, Wallukat G, Wolf M, Herse F, Rajakumar A, Roberts JM, Markovic N, Thadhani R, Luft FC, Dechend R. Agonistic AT1-receptor autoantibodies in women with a history of preeclampsia. Hypertension 2007 (in press).

527. Gueler F, Park J-K, Rong S, Kirsch T, Lindschau T, Zheng W, Elger M, Fiebeler A, Fliser D, Luft FC, Haller H. Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages. Am J Pathol 2007 (in press).

528. Von Vietinghoff S, Tünnemann G, Eulenberg C, Wellner M, Cardoso M-C, Luft FC, Kettritz R. NB1 mediates expression of the ANCA antigen proteinase 3 on human neutrophils. Blood 2007 (in press).

529. Schafflhuber M, Volpi N, Dahlmann A, Hilgers KF, Maccari F, Dietsch P, Wagner H, Luft FC, Eckardt K-U, Titze J. The molbilization of osmotically inactive Na+ by growth and by dietary salt restriction in rats. Am J Physiol 2007 (in press).

European Fellows program

Specify if the Unit accepts fellows from European countries for:

Short (1-2 month) well focused training programs either clinically or laboratory oriented: flexible

Long (at least 1 year) research fellowships: flexible

Specify corresponding availability of grants: grants are possible, but highly competitive

Specify if the Unit may provide help for accommodation: Help with accommodation is possible.

Prerequisites for Fellowship

Language (specify) Fluency in English is necessary; if clinical training is desired, some knowledge of German is no hindrance.

Work/Research experience (specify) An excellent previous track-record is helpful.

Other prerequisites (specify)

We are interested in a few bright young people who want to make a difference. Our mission is training clinician-scientists. More information can be obtained from the Max Delbrück Center for Molecular Medicine website.