Turin
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Turin |
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The Taurini, a people of Celtic origin, lived here. The city was destroyed by Hannibal in 221 BC during his descent from the Alps towards Rome. Augustus renamed the city Augusta Taurinorum. The city was plundered by the Lombards and then taken over from the duke by the Count of the Carolingians. The most important Marquis was Olderico whose death led to the succession of the Counts of Savoy. Nonetheless, Turin was not immediately handed over to the House of Savoy, although they had the title of Marquis they had to share power with the bishop for a long time. After mixed fortunes, Amedeo III took control of the city, which then passed into the hands of Angioini and on to Guglielmo XII, Marquis of Monferrato who lost it to Tommaso III. From then on the House of Savoy continued to rule until the sixteenth century. The city was then entrusted to the French king Francesco I, whose successor returned it to Emanuele Filiberto. The French were frequently involved in disputes over the successors and alternately backed the success of one pretender or other. From 1800 to 1814 Turin was the capital of the French department of the Po, and in 1815 the House of Savoy was restored. Ever since then the history of Turin has merged with the State of Savoy and, subsequently that of Italy.
In 1848 Piedmont was at the centre of the first Italian war of independence. The Piedmontesi defeated the Austrians at Pastrengo and then, thanks to the endurance of Tuscan volunteers at Curtatone and Montanara, they managed to overcome them at Goito. On the 30th October, Carlo Alberto was crowned King of Italy. However, the war rapidly turned against the Piedmontesi who were forced to surrender to the Austrians and give up Tuscany. After the annexation of Lombardy, Tuscany, Emilia and Romagna, and the Papal State, the international policies of Cavour and the exploits of Garibaldi, who conquered the Kingdom of the Due Sicilie in February 1861, Vittorio Emanuele II was proclaimed King of Italy on the 18th February. The capital was originally in Turin but was moved to Rome on the 27th March. The Albertine Statute celebrated fifty years in 1898.
Over time Turin became more and more industrialised and it was therefore heavily bombed during the Second World War by the Allies and later subjected to terrible destruction by the retreating Germans. In the 1950's Fiat played an essential role in the re-development of the city, and, after a period of recession in the 1980's, it gained importance in the 1990's as one of the most developed technological regions. Thanks to Turin's new image, the city hosted the winter Olympics in 2006.
| HEAD OF THE UNIT | Rosanna Coppo, MD |  |
| CLINICAL STAFF | A. Amore, G. Porcellini, B. Gianoglio, L. Peruzzi, R. Bonaudo, M. Gaido, D. Mancuso (Fellowship recipient) |  |
| RESEARCH AND LABORATORY |  |
A. Amore, L. Peruzzi, S. Balegno, L. Ghisellini, D. Mancuso, R. Camilla, F. Magnetti, D. Mancuso (Fellowship recipient) |
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CONTACT
INFORMATION |
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| nefrologia@oirmsantanna.piemonte.it | |
| PHONE: | +39 011 3135848 |
| FAX: | +39 011 6635543 |
| FULL POSTAL ADDRESS | Piazza Polonia 94, 01026, Torino, Italy |
| WEBSITE | http//www.oirmsantanna.piemonte.it |
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CLINICAL
FACILITIES |
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| NEPHROLOGY BEDS N° | 5 Nephrology + 2 Transplantation (in 2004: 296 patients hospitalized;1212 day hospital accesses, 30 renal biopsies, 6 differently specialized out-patient clinic accesses) |
| HEMODIALYSIS PATIENTS N° | In 2004: 142 treatments for chronic children, 31 for children in acute renal failure. |
| PERITONEAL DIALYSIS PATIENTS N° | 5 children in home APD (1171 treatments); 166 treatments for children in acute renal failure |
| INTENSIVE CARE NEPHROLOGY BEDS N° | 2 |
| RENAL TRANSPLANTS /YEAR (2001) N° | 5 (62 children and young adults with functioning renal graft followed in out-patient clinic) |
RESEARCH INTERESTS
CLINICAL RESEARCH
RESEARCH PROGRAMME AND PROJECTS LIST
1) Clinical features, therapy and immunobiology of IgA nephropathy (IgAN). R. Coppo is the Secretary of the International IgAN Network (Convenor: J.Feehally).
Projects:
3) Treatment of Lupus Nephritis with mycophenolate mofetil: International Prospective Trial
4) ESCAPE International trial for optimization of blood pressure control, leaded by F.Schaefer (Heidelberg): Turin Unit. Enrolment of children with CRF.
5) European Hospal Grant: In vitro and in vivo modulation of molecular mechanisms activated in diabetic patients in chronic dialysis triggering the cardiovascular risk. Study in vitro and in vivo on the potential protective role of N-acetyl-cysteine (NAC) in diabetic patients in hemodialysis. Turin Center: Coordination of patients enrolment and Laboratory studies, including transcriptional factor activation (NF-kB), NOS activity, apoptosis, AOPP, total antioxidant capacity (TAC) before and after treatment with NAC 1 gr/iv each dialysis session. In vitro study on the effects of pro-oxidant molecules involved in the pathogenesis of diabetic and dialytic vasculopathy (i.e. carbonylic compounds, AGEs, ALEs, AOPP, oxized LDL) on endothelial cells biology and their prevention by anti-oxidants.
6) Clinical Trial in Transplanted children on Rapamycin. Open-label single-arm pilot study to evaluate the effect of rapamycin and steroids following calcineurine inhibitors reduction in pediatric renal allograft recipients with progressive impairment of renal function. Turin Center. Enrolment of transplanted children.
7) Clinical Trial in Transplanted children on steroid withdrawal. Open, randomized, multicentre clinical study to investigate the safety and efficacy of steroid withdrawal with tacrolimus, mycophenolate mofetil and daclizumab against tacrolimus, mycophenolate mofetil and steroids in children after kidney transplantation. Turin Center. Enrolment of transplanted children.
8) Regional Registry of children with chronic diseases leading to organ transplantation:
Network supported by the Piedmont Region Health System to gather epidemiological data on kidney or liver or heart or lung chronic insufficiency with possible future need of organ transplantation.
BASIC RESEARCH
Peer Reviewed Publications in International Journals (only English) 2000-2002
Publications list:
Some selected publications of the Unit are:
2005
Amore A, Coppo R. Effects on the immune system: Oxford Textbook of Clinical Nephrology, 3rd Edizione (Davison A et al Eds). Oxford University Press, Oxford, UK.pag 1868-1874, 2005
Coppo R, Amore A. Henoch-Schoenlein purpura Oxford Textbook of Clinical Nephrology, 3rd Edizione (Davison A et al, Eds). Oxford University Press, Oxford, UK. pag 753-765, 2005
Schena FP, Coppo R. IgA nephropathies. Oxford Textbook of Clinical Nephrology, 3rd Edizione (Davison A et al, Eds). Oxford University Press, Oxford, UK. pag 469-502, 2005
Ferraresso M, Ghio L, Zacchello G, Murer L, Ginevri F, Perfumo F, Zanon GF, Fontana I, Amore A, Edefonti A, Vigano S, Cardillo M, Scalamogna M.
Pharmacokinetic of cyclosporine microemulsion in pediatric kidney recipients receiving A quadruple immunosuppressive regimen: the value of C2 blood levels.
Transplantation. 2005: 15;79(9):1164-8
Coppo R, Amore A, Peruzzi L, Conti G, Roasio L, Amoroso A.
Kidney transplantation in children
G Ital Nefrol. 2005 22(4):337-47
Conti G, Amore A, Chiesa M, Mancuso D, Cirina P, Mengozzi G, Santoro A, Coppo R.
Procalcitonin as a marker of micro-inflammation in hemodialysis.
J Nephrol. 2005 ;18(3):282-8.
Peruzzi L, Lombardo F, Amore A, Merlini E, Restagno G, Silvestro L, Papalia T, Coppo R.
Low renin-angiotensin system activity gene polymorphism and dysplasia associated with posterior urethral valves.
J Urol. 2005 ;174(2):713-7.
Dal Canton A, Amore A, Barbano G, Coppo R, Emma F, Grandaliano G, Klersy C, Perfumo F, Rizzoni G, Schena FP, Sepe V.
Angiotensin Inhibition Mycophenolate mophetil IgA Nephropathy study investigators.
One-year angiotensin-converting enzyme inhibition plus mycophenolate mofetil immunosuppression in the course of early IgA nephropathy: a multicenter, randomised, controlled study.
J Nephrol. 2005;18(2):136-40.
2004
Coppo R, Amore A. Henoch-Schoenlein purpura (Coppo R, Amore A). Pediatric Nephrology (5a edizione) Avner ED, Harmon WE, Niaudet P Eds. Lippincot Williams and Wilkins Editor, Philadelphia, Baltimore, New-York, London, Buenos Aires, Hong Kong, Sidney, Tokyo. pag 851-864, 2004.
Amore A, Coppo R, Nedrud JG, Sigmund N, Lamm ME, Emancipator SN.
The role of nasal tolerance in a model of IgA nephropathy induced in mice by Sendai virus.
Clin Immunol. 2004 ;113(1):101-8.
Coppo R, Menè P
Glomerulonephritis and renal sclerosis: new therapeutic proposal
G Ital Nefrol 2004; 21: 217-224
Coppo R, Amore A.
Aberrant glycosylation in IgA nephropathy (IgAN).
Kidney Int. 2004 ;65:1544-7.
Coppo R
A severe case of nephrotic syndrome
G Ital Nefrol 2004: 30:185-197
Coppo R, Amore A.
New perspectives in treatment of glomerulonephritis.
Pediatr Nephrol. 2004;19(3):256-65
Amore A, Cirina P, Conti G, Cerutti F, Bagheri N, Emancipator SN, Coppo R.
Amadori-configurated albumin induces nitric oxide-dependent apoptosis of endothelial cells: a possible mechanism of diabetic vasculopathy.
Nephrol Dial Transplant. 2004 ;19:53-60.
Amore A, Conti G, Cirina P, Peruzzi L, Mollo A, Chiesa M, Turcato S, Ghisellini L, Coppo R.
Biocompatibility of the acetate in the dialysis fluid
G Ital Nefrol. 2004;21 Suppl 30:S91-6
2003
Coppo R, Amore A. Vasculitis (ANCA negative): Henoch Schoenlein purpura . In Rheumatology and the kidney, Adu D, Emery P, Madaio M Eds, Oxford University Press, Oxford, UK, pag 246-257, 2003
Gianviti A, Tozzi AE, De Petris L, Caprioli A, Rava L, Edefonti A, Ardissino G, Montini G, Zacchello G, Ferretti A, Pecoraro C, De Palo T, Caringella A, Gaido M, Coppo R, Perfumo F, Miglietti N, Ratsche I, Penza R, Capasso G, Maringhini S, Li Volti S, Setzu C, Pennesi M, Bettinelli A, Peratoner L, Pela I, Salvaggio E, Lama G, Maffei S, Rizzoni G.
Risk factors for poor renal prognosis in children with hemolytic uremic syndrome.
Pediatr Nephrol. 2003 Dec;18(12):1229-35.
Conti G, Gaido M, Amore A, Coppo R, Saracco P, Fagioli F.
Renal transplantation and immunosuppressive therapy do not contraindicate stem-cell donation for bone-marrow transplantation.
Transplantation. 2003; 27;76(12):1771.
Amore A, Cappelli G, Cirina P, Conti G, Gambaruto C, Silvestro L, Coppo R.
Glucose degradation products increase apoptosis of human mesothelial cells.
Nephrol Dial Transplant. 2003;18(4):677-88.
2002
Coppo R, Peruzzi L, Porcellini G, Amore A, Conti G. Renal disorderd in neonates and young children in Nephrology. FP Schena Editor. Mc Graw-Hill International UK LTD. London, pag 479- 485, 2002
Amore A, Besbas N. Immunology of Transplantation.
In ESPN (European Society for Pediatric Neprology) Handbook. P Cochat Ed, Medcom, Lyon Editor, France, pag 427-429, 2002
Coppo R, Nagy J IgA Nephropathy
In ESPN (European Society for Pediatric Neprology) Handbook. P Cochat Ed, Medcom, Lyon Editor, France, pag 275-283, 2002
Coppo R, Chiesa M, Cirina P, Peruzzi L, Amore A; European IgACE Study Group.
In human IgA nephropathy uteroglobin does not play the role inferred from transgenic mice.
Am J Kidney Dis. 2002
Amore A, Coppo R.
Immunological basis of inflammation in dialysis.
Nephrol Dial Transplant. 2002;17 Suppl 8:16-24. Review.
Piccoli A, Fanos V, Peruzzi L, Schena S, Pizzini C, Borgione S, Bertino E, Chiaffoni G, Coppo R, Tato L.
Reference values of the bioelectrical impedance vector in neonates in the first week after birth.
Nutrition. 2002 May;18(5):383-7
2001
Amore A, Cirina P, Conti G, Brusa P, Peruzzi L, Coppo R.
Glycosylation of circulating IgA in patients with IgA nephropathy modulates proliferation and apoptosis of mesangial cells.
J Am Soc Nephrol. 2001 Sep;12(9):1862-71.
Coppo R, Chiesa M, Peruzzi L, Amore A.
Treatment of IgA nephropathy with angiotensin converting enzyme inhibitors: design of a prospective randomized multicenter trial.
J Nephrol. 2001 Nov-Dec;14(6):447-52.
Peruzzi L, Amore A, Cirina P, Chiesa M, Coppo R.
Tubular cells trans-differentiation induced by allogenic response can be modulated by cyclo-oxygenase-2 inhibitors.
Transplant Proc. 2001 Nov-Dec;33(7-8):3349-50
Amore A, Cirina P, Chiesa M, Conti G, Peruzzi L, Coppo R.
Graft endothelium and chronic allograft nephropathy: insight from in vitro trans-differentiation of smooth muscle cells induced by mismatched lymphocytes.
Transplant Proc. 2001 Nov-Dec;33(7-8):3347-8.
Conti G, Amore A, Cirina P, Gianoglio B, Peruzzi L, Coppo R.
Cyclosporin induces apoptosis of renal cells by enhancing nitric oxide synthesis: modulating effect of angiotensin II inhibitors.
Transplant Proc. 2001 Feb-Mar;33(1-2):276-7.
Cappelli G, Amore A, Bandiani G, Cancarini G, Coppo R, Feriani M, Dell'Aquila R, Saffioti S, Spisni C, Stingone A, Orazi E, Ballocchi S, Renaux JL.
A peritoneal dialysis solution prepared from a three-compartment bag: biological and clinical effects.
Contrib Nephrol. 2001;(131):97-106.
Peruzzi L, Amore A, Cirina P, Chiesa M, Coppo R.
Tubular cells trans-differentiation induced by allogenic response can be modulated by cyclo-oxygenase-2 inhibitors.
Transplant Proc. 2001 Nov-Dec;33(7-8):3349-50
2000
Coppo R, Amore A
Pathogenetic aspects of IgAN
In: Moderately proteinuric IgA nephropathy in the young. European Commission Science, research and Development. R Coppo, L Peruzzi Eds. Biomedical and Health research. IOS Press, Ohmasha, Amsterdam, Berlin, Oxford, Tokio, Washington DC, Vol 44: pag 1-6, 2000
Amore A, Emancipator SN, Cirina P, Conti G, Ricotti E, Bagheri N, Coppo R.
Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells.
Kidney Int. 2000 Apr;57(4):1549-59.
Amore A, Coppo R.
Modulation of mesangial cell reactivity by aberrantly glycosylated IgA.
Nephron. 2000 Nov;86(3):255-9. Review.
Amore A, Conti G, Cirina P, Peruzzi L, Alpa M, Bussolino F, Coppo R.
Aberrantly glycosylated IgA molecules downregulate the synthesis and secretion of vascular endothelial growth factor in human mesangial cells.
Am J Kidney Dis. 2000 Dec;36(6):1242-52.
Coppo R, Amore A, Hogg R, Emancipator S.
Idiopathic nephropathy with IgA deposits.
Pediatr Nephrol. 2000 Nov;15(1-2):139-50. Review.
Peruzzi L, Amore A, Cirina P, Trusolino L, Basso G, Ricotti E, Emancipator SN, Marchisio PC, Coppo R.
Integrin expression and IgA nephropathy: in vitro modulation by IgA with altered glycosylation and macromolecular IgA.
Kidney Int. 2000 Dec;58(6):2331-40.
Amore A, Coppo R.
Role of apoptosis in pathogenesis and progression of renal diseases.
Nephron. 2000 Oct;86(2):99-104. Review.
Coppo R, Amore A.
Importance of the bradykinin-nitric oxide synthase system in the hypersensitivity reactions of chronic haemodialysis patients.
Nephrol Dial Transplant. 2000 Sep;15(9):1288-90.
Coppo R, Amore A, Cirina P, Scelfo B, Giacchino F, Comune L, Atti M, Renaux JL.
Bradykinin and nitric oxide generation by dialysis membranes can be blunted by alkaline rinsing solutions.
Kidney Int. 2000 Aug;58(2):881-8.
Adelman RD, Coppo R, Dillon MJ.
The emergency management of severe hypertension.
Pediatr Nephrol. 2000 May;14(5):422-7. Review
Cirina P, Chiesa M, Amore A, Coppo R
Macromolecular IgA and IgA with altered glycosylation. In: Moderately proteinuric IgA nephropathy in the young. European Commission Science, research and Development. R Coppo, L Peruzzi Eds. Biomedical and Health research. IOS Press, Ohmasha, Amsterdam, Berlin, Oxford, Tokio, Washington DC, Vol 44: pag 88-96, 2000
Chiesa M, Cirina P, Peruzzi L, Amore A, Coppo R
Blastokinin/Uteroglobin in sera of IgAN patients. In: Moderately proteinuric IgA nephropathy in the young. European Commission Science, research and Development. R Coppo, L Peruzzi Eds. Biomedical and Health research. IOS Press, Ohmasha, Amsterdam, Berlin, Oxford, Tokio, Washington DC, Vol 44: pag 97-103, 2000
Conti G, Cirina P, Amore A
IL-6, IL-8. MCP-1 and EGF urinary cytokine excretion in IgA nphropathy. In: Moderately proteinuric IgA nephropathy in the young European Commission Science, research and Development. R Coppo, L Peruzzi Eds. Biomedical and Health research. IOS Press, Ohmasha, Amsterdam, Berlin, Oxford, Tokio, Washington DC, Vol 44: pag 97-103, 2000
European
Fellows programme
Short (1-2 month) well focused training programs either clinically or laboratory
oriented: yes on individual basis on specific needs.
Long (at least 1 year) research fellowships yes for basic research programme
Specify corresponding availability of grants
Yes for some specific projects; arrangements can be made in case of external funding provided by the fellow
Specify if the Unit may provide help for accommodation: YES, as limited support for accomodation
Prerequisites
for Fellowship
Language: English, French and Spanish.
Work/Research experience: Nephrologists or Pediatricians for Clinical programmes. Research oriented Nephrologists or Biologists for Basic science programmes.
Cv evaluation: yes
