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| HEAD OF THE UNIT | György Kakuk, M.D., Ph.D. | |
| CLINICAL STAFF | Associate
Professors: Senior
Lecturers: Lecturers:
Fellows
in Nephrology: Resident:
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| RESEARCH AND LABORATORY | József
Balla, M.D., D.Sc. Zsuzsa Varga, Ph.D. Viktória Jeney, Ph.D. Emoke Nagy, in Ph.D. program |
| CONTACT
INFORMATION |
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| kakuk@ibel.dote.hu | |
| PHONE: | +36-52-414-227/413-653 |
| FAX: | +36-52-414-951 |
| FULL POSTAL ADDRESS | Nagyerdei krt. 98, H-4012 Debrecen, Hungary |
| CLINICAL
FACILITIES |
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| NEPHROLOGY BEDS N° | 34 | |
| HEMODIALYSIS PATIENTS N° | 142 |  |
| PERITONEAL DIALYSIS PATIENTS N° | 1 | |
| INTENSIVE CARE NEPHROLOGY BEDS N° | 4 | |
| RENAL TRANSPLANTS /YEAR (2001) N° | 40 | |
RESEARCH INTERESTS
CLINICAL RESEARCH
RESEARCH PROGRAMMES
AND PROJECTS LIST
1. Examination of arrhythmogenesity with non-invasive methods in uremic patients.
2. Altered iron metabolism in ESRD.
3. Study of the risk factors of atherosclerosis in end stage renal disease
such as hyperhomocysteinemia, lipids and fatty acids.
4. Study of the functional modification of mono-and polymorphonuclear leukocytes
in uremic patients.
5. Oxidative resistance of LDL and antioxidant capacity of the plasma of uremic
patients.
6. Genetic diseases (XLHN, MCKD).
7. Long term consequences of hemodialysis (ACKD, amyloidosis, atherosclerosis,
Ca-P disorders).
8. Collagen III. in renal diseases. Sustainable quality of life in renal and
cardiac patients. Patient education and health promotion.
9. Epidemiology and quality of life related research.
10. Epidemiology of hypertension and its risk factors in Debrecen.
11. Epidemiological study of juvenile hypertension in Debrecen.
BASIC RESEARCH
1. Role of heme
proteins, heme oxygenase and ferritin in free radical mediated vascular endothelial
and tubular epithelial cell injury.
2. Mechanism of LDL oxidation. Oxidative resistance of LDL. Antioxidant capacity
of biological fluids.
3. New small molecular weight uremic toxins and their biological properties
and effects.
4. Study of the antioxidant activity and signal transduction mechanism of
newly synthesized antioxidants.
5. Induction of oxidative stress and stress-adaptation by ferriporphyrins
and heme proteins.
6. Determination of aluminium and other trace elements in chronic renal failure
patients.
7. Synthesis of new flavonolignans and study of their antioxidant properties.
Peer Reviewed Publications in International Journals (only English) 2000-2002
European
Fellows programme
Short (1-2 month) well focused training programs either clinically or laboratory
oriented: Accepts. As listed above in Clinical and Basic Research.
Long (at least 1 year) research fellowships: Accepts. As listed above in Clinical and Basic Research.
Specify corresponding availability of grants Yes
Specify if the Unit may provide help for accommodation Yes
Prerequisites
for Fellowship
Language: English, German, Hungarian.
Work/Research experience: Physicians or researchers interested and experienced in clinical or basic research.
