EUROPEAN TRAINING CENTRES

Wroclaw	Wroclaw Medical University

RESEARCH INTERESTS

 

CLINICAL RESEARCH

RESEARCH PROGRAMMESS AND PROJECTS LIST

•	Primary and secondary glomerulonephritis. Clinical symptoms severity (hypertension and magnitude of proteinuria) and activity and chronicity indices in renal biopsy studies - impact on long-term course of primary glomerulonephritis. The significance IgG/IgM ratio in daily proteinuria for the treatment response and long-term prognosis in different types of glomerulonephritis.   Immunosupressive programs in the treatment of primary and secondary (lupus nephritis, vasculitis) glomerulonephritis - efficacy in long-term follow-up.
•	Haemodialysis. Factors affecting cardiovascular morbidity and mortality of haemodialysis population - the significance of low fetuin-A level, hyperhomocysteinemia, ADMA (acyclic dimethylarginine), low-molecular protein-bound toxins (inoxyl sulphate, p-cresol, phenol) and inflammatory indices (IL-1, IL-6, IL-18  a.o.) in relation with pulse weave velocity (PWV) measurements. Vascular access creation in high risk, elderly and diabetic haemodialysis patients - own original method of the native arteriovenous fistula formation with use of perforating vein connected end-to-end to radial artery in patient with destroyed superficial veins. Elaboration of the method of the wrist native arteriovenous fistula superficialization in obese patients.     http://www.asdin.org/Visitors/Nephrologybiblio/bib-SDVA.cfm
•	Peritoneal dialysis. Peritoneal dialysis treatment of high risk patients (diabetics, with cardiovascular instability) - value of the PD-treatment and it’s impact on morbidity and mortality. Patients with high permeability of peritoneal membrane - efficacy of continuous cyclic peritoneal dialysis. Removal of the low-molecular protein-bound toxins - comparison between peritoneal dialysis and haemodialysis. Quality of life of patients on HD- and CAPD-treatment. Individualization of renal replacement therapy in the elderly patients and diabetics.
•	Kidney allografts. Cytodiagnostic of urinalysis for monitoring renal allograft injury. Chronic allograft nephropathy - the effect of MMF-treatment. Viral infection following renal transplantation (CMV, HSV, polyoma). The role of genetic polymorphism of interleukins and co-stimulatory molecules. Optimalization of immunosupression after renal transplantation e.g. early steroid withdrawal in the kidney graft recipients and replacement of calcineurin inhibitors by less nephrotoxic immunosupressive agents - conversion criteria.

BASIC RESEARCH

RESEARCH PROGRAMMESS AND PROJECTS LIST

•	Characterisitics of cytokines and growth factors pattern in kidney allograft biopsy specimens; relation to ischaemic/reperfusion injury, acute and chronic allograft rejection and calcineurin inhibitors toxicity
•	Cytokine gene polymorphism and intensity of acute and chronic kidney allograft rejection
•	Assessment of the kidney transplant recipients alloreactivity using ELISPOT assay
•	CTLA4 and CD40L expression on T lymphocytes in kidney transplant recipients
•	Indices of immunologic tolerance in the recipients with long-term functioning graft on minimal immunosupression
•	Neutrophils involvement in the pathogenesis of the primary and secondary glomerulonephritis
•	Localization of elastase deposits in renal tissue and assessment of relationship with urinary excretion

 

Peer Reviewed Publications in International Journals (only English) 2000-2005

 

European Fellows programme

Short (1-2 month) well focused training programs either clinically or laboratory oriented: specific trainig in the formation of different variants of arteriovenous fistulas and in the care or renal transplants recipients.

Long (at least 1 year) research fellowships: possibility of the application for Ph.D. fellowship.

Specify corresponding availability of grants: YES, possibility of the application for grants from Polish Governmental Committee for Scientific Research and funds from EU.

Specify if the Unit may provide help for accommodation: Yes.

 

Prerequisites for Fellowship

Language: English is compulsory, for patients care basic knowledge of Polish is desirable.

Work/Research experience: will be discussed individually with candidate.

Other prerequisites: possibility of preliminary course in Polish is offered.