| Title
of the article |
Tacrolimus exposure and evolution of renal allograft histology in the first year after transplantation. |
| Authors |
Naesens M, Lerut E, Damme BV, Vanrenterghem Y, Kuypers DR. |
| Journal
|
Am J Transplant. 2007 Sep;7(9):2114-23. Epub 2007 Jul 3. |
| Subject
Consultant |
B. Watschinger |
| Score
(1 to 3 stars) |
** |
| Comments |
Biopsy-proven acute rejection episodes and low mean tacrolimus exposure were independently associated with higher increase in chronicity scores between 3 and 12 months after transplantation. This observational study in 120 pattients suggests that rejection phenomena and immune-mediated mechanisms remain important in the early progression of chronic allograft pathology. |
