SUBJECT CONSULTANT REVIEW

Title of the article
Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection.
Authors

Everly MJ, Everly JJ, Susskind B, Brailey P, Arend LJ, Alloway RR, Roy-Chaudhury P, Govil A, Mogilishetty G, Rike AH, Cardi M, Wadih G, Tevar A, Woodle ES.

Journal

Transplantation. 2008 Dec 27;86(12):1754-61.

Subject Consultant
B. Watschinger
Score (1 to 3 stars)
***
Comments
Bortezomib a first in class proteosomal inhibitor for the treatment of multiple myeloma was succefully used as an antirejection strategy targeting plasma cells. This is a new strategy that could prove potentially successful in the future.