| Title
of the article |
Neutrophil gelatinase-associated lipocalin in patients with autosomal-dominant polycystic kidney disease. |
| Authors |
Bolignano D, Coppolino G, Campo S, Aloisi C, Nicocia G, Frisina N, Buemi M. |
| Journal
|
Am J Nephrol. 2007;27(4):373-8. |
| Subject
Consultant |
A. Wiecek |
| Score
(1 to 3 stars) |
** |
| Comments |
The strict correlation between NGAL levels and residual renal function is perfectly in accord with recent studies on patients with other ESRD-associated diseases. Authors can hypothesize that tubular cells produce big quantities of NGAL as a consequence of increased apoptosis following chronic damage or as a compensatory response, similar to that observed in acute stress conditions (ischemia, toxicity ...). Finally, last finding that patients with HCG showed higher levels of NGAL suggests that this protein could be also involved in the cyst growth process, as previously reported about epithelial and tumoral expansion. |
