| Title
of the article |
Factors predicting the Near-Final Height in Growth Hormone treated Children and Adolescents with Chronic Kidney Disease. |
| Authors |
Nissel R, Lindberg A, Mehls O, Haffner D; on behalf of the KIGS International Board. |
| Journal
|
J Clin Endocrinol Metab. 2008 |
| Subject
Consultant |
A. Wiecek |
| Score
(1 to 3 stars) |
** |
| Comments |
Mean height SD scores (SDS) increased continuously during GH treatment until near-FH (FH = final height) by 1.2 and 1.6 in boys and girls, respectively. Mean near-FH differed significantly from prepubertal patients showing severely delayed puberty (-3.6), late pubertal patients (-2.9), early pubertal patients (-2.2) and prepubertal patients with normal onset of puberty (-2.0). The initial degree of stunting, degree of bone age retardation, duration of GH therapy, time spent on conservative treatment/dialysis, pubertal delay (> 2SD), gender and age at start of GH treatment were significant predictors of growth response to GH therapy, explaining between 33% and 61% of the overall variability. Long-term GH therapy of CKD patients in prepubertal and pubertal age results in an increased adult height, but response is diminished in patients on dialysis and/or with severely delayed puberty. |
