| Title
of the article |
Renal toxicity mediated by glucose degradation products in a rat model of advanced renal failure. |
| Authors |
Müller-Krebs S, Kihm LP, Zeier B, Gross ML, Deppisch R, Wieslander A, Henle T, Penndorf I, Oh J, Reiser J, Nawroth PP, Zeier M, Schwenger V. |
| Journal
|
Eur J Clin Invest. 2008 May;38(5):296-305. Epub 2008 Mar 16. |
| Subject
Consultant |
A. Wiecek |
| Score
(1 to 3 stars) |
*** |
| Comments |
The subtotal nephrectomy (SNX) + glucose degradation products (GDP) rats developed significantly more albuminuria and showed a significantly higher score of glomerulosclerosis index (GSI) and tubulointerstitial damage index (TII) as compared to SNX or control rats. In the SNX + GDP group the expression of carboxymethyllysine and methylglyoxal was significantly higher in the tubulointerstitium and the glomeruli compared to the SNX rats. Caspase 3 staining and TUNEL assay were more pronounced in the tubulointerstitium and the glomeruli of the SNX + GDP group. In SNX + GDP animals, the expression of the slit diaphragm protein nephrin, was significantly lower compared to SNX or control animals. Therefore GDP can significantly advance chronic kidney disease and argues that peritoneal dialysis (PD) solutions containing high GDP might deteriorate residual renal function in PD. |
