| Title
of the article |
Association of serum adiponectin levels with all-cause mortality in hemodialysis patients. |
| Authors |
Ohashi N, Kato A, Misaki T, Sakakima M, Fujigaki Y, Yamamoto T, Hishida A. |
| Journal
|
Intern Med. 2008;47(6):485-91. Epub 2008 Mar 17. |
| Subject
Consultant |
A. Wiecek |
| Score
(1 to 3 stars) |
*** |
| Comments |
Cox-hazards multivariate regression analysis adjusted for conventional case-mix features (age, sex, and underlying kidney disease) revealed that serum ADPN became a significant determinant of all-cause mortality. There was a 10.3% risk increment for each 1-microg/ml increase in ADPN during the follow-up. Kaplan-Meier analysis revealed that patients with higher ADPN levels (> or =15 microg/ml) had a significantly lower survival rate compared with those with lower ADPN levels (<15 microg/ml) (76 vs. 92%, p<0.05). These results indicated that high rather than low ADPN independently predict total mortality in HD patients. |
