| Title
of the article |
BMP-7 Is an Efficacious Treatment of Vascular Calcification in a Murine Model of Atherosclerosis and Chronic Renal Failure. |
| Authors |
Davies MR, Lund RJ, Hruska KA. |
| Journal
|
J Am Soc Nephrol. 2003 Jun;14(6):1559-67. |
| Subject
Consultant |
C. Zoccali |
| Score
(1 to 3 stars) |
*** |
| Cross
referencing |
Hemodialysis, Chronic Renal failure |
| Comments |
Bone morphogenetic protein 7 (BMP-7) is an essential renal morphogen that maintains renal tubular differentiation in the adult and is downregulated in renal failure. It was hypothesized that BMP-7 could be an effective treatment of vascular calcification ESRD. In the LDL receptor null mice (a model of atherosclerosis) BMP-7 seems to an useful treatment of vascular calcification. |
